Genetic characterization of avian polyomaviruses identified from psittacine birds in South Korea.

IF 2.5 2区农林科学 Q1 VETERINARY SCIENCES

Avian Pathology Pub Date : 2023-12-01 Epub Date: 2023-09-06 DOI:10.1080/03079457.2023.2247347

Ye-Ji Yun, HyeSoon Song, Yong-Kuk Kwon, Choi-Kyu Park, Hye-Ryoung Kim

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引用次数: 0

Abstract

Budgerigar fledgling disease (BFD) is a contagious disease caused by avian polyomavirus (APV) in psittacine birds and causes high mortality rates. Here, eight APV-positive cases were confirmed from dead parrots or parrot tissue samples by polymerase chain reaction (PCR). Full-length genome sequencing showed high nucleotide identity (98.84-100%) between the APV strains. Phylogenetic analysis revealed that two genogroups were cocirculating in South Korea. The nucleotide sequences of five strains, collected from different parrot species, were identical; however, pathological lesions were observed in only two parrots, both aged 2 months. Pathology included necrotic spots in the liver, subcutaneous haemorrhage, hepatomegaly, ascites, intranuclear inclusion bodies, hepatocyte karyomegaly, hepatic necrosis, and bile duct proliferation. This suggests that the pathogenicity of APV might be host age-dependent regardless of the host species. This study improves our understanding of APV pathogenicity and provides a more detailed genetic characterization of APV strains.RESEARCH HIGHLIGHTS Eight APV strains were identified in South Korea from 2019 to 2021.By phylogenetic analysis, South Korean APV strains were classified into two clades.

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从韩国鹦鹉螺属鸟类中鉴定出的鸟类多瘤病毒的遗传特征。

Budgerigar雏鸟病（BFD）是一种由鹦鹉多瘤病毒（APV）引起的传染性疾病，死亡率很高。在这里，通过聚合酶链式反应（PCR）从死鹦鹉或鹦鹉组织样本中确认了8例APV阳性病例。全长基因组测序显示APV菌株之间具有较高的核苷酸同一性（98.84-100%）。系统发育分析显示，两个基因组在韩国是共循环的。从不同鹦鹉物种采集的五个菌株的核苷酸序列是相同的；然而，仅在两只鹦鹉身上观察到病理病变，它们都是2个月大的。病理学包括肝脏坏死点、皮下出血、肝肿大、腹水、核内包涵体、肝细胞核肿大、肝坏死和胆管增生。这表明APV的致病性可能与宿主年龄有关，而与宿主物种无关。这项研究提高了我们对APV致病性的理解，并提供了更详细的APV菌株的遗传特征。研究亮点2019年至2021年，韩国共鉴定出8株APV菌株。通过系统发育分析，韩国APV菌株分为两个分支。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Avian Pathology 农林科学-兽医学

CiteScore

4.50

自引率

10.70%

发文量

审稿时长

1 months

期刊介绍： Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.