Scleroderma specific autoantibodies in rheumatoid arthritis and Sjögren's syndrome patients with interstitial lung disease: Prevalence and associations

IF 4.7 Q2 IMMUNOLOGY

Journal of Translational Autoimmunity Pub Date : 2023-01-01 DOI:10.1016/j.jtauto.2022.100183

Vasiliki Koulouri , Athanasios-Dimitrios Bakasis , Nikolaos Marketos , Kyriaki Tavernaraki , Mayra Giannelou , Haralampos M. Moutsopoulos , Clio P. Mavragani

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Abstract

Systemic sclerosis (SSc) has been classically linked to interstitial lung disease (ILD) development, often in association with specific SSc autoantibodies. In the present report, we aimed to estimate the prevalence of SSc autoantibodies in 60 seropositive RA and 41 primary SS patients complicated or not by ILD. SSc autoantibodies were determined in patients’ sera by a commercial immunoblot assay. RA ILD patients displayed higher frequency of SSc-specific antibodies at strong titers compared to RA-with no lung involvement (25% vs 3.1%, p = 0.01)[OR 95% CI:10.9 (1.2–94.5)], with no differences detected between primary SS groups. These data indicate that many seropositive RA ILD patients probably represent an overlap RA/SSc entity, requiring tailored diagnostic and therapeutic approach.

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类风湿性关节炎和Sjögren综合征合并间质性肺病患者的硬皮病特异性自身抗体:患病率和相关性

系统性硬化症(SSc)通常与间质性肺疾病(ILD)的发展有关，通常与特异性SSc自身抗体相关。在本报告中，我们旨在估计60例血清阳性RA和41例合并或不合并ILD的原发性SS患者中SSc自身抗体的患病率。通过商业免疫印迹法测定患者血清中的SSc自身抗体。与没有肺部受损伤的RA相比，RA ILD患者显示出更高频率的ssc特异性抗体(强滴度)(25% vs 3.1%， p = 0.01)[OR 95% CI:10.9(1.2-94.5)]，在原发性SS组之间没有发现差异。这些数据表明，许多血清阳性的RA ILD患者可能代表了重叠的RA/SSc实体，需要定制诊断和治疗方法。

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