Adenovirus 36 Coinfection in People Living with HIV and its Impact on Lipohypertrophy.

IF 0.8 4区医学 Q4 IMMUNOLOGY

Current HIV Research Pub Date : 2023-01-01 DOI:10.2174/1570162X21666230420090756

Helena Caetano Gonçalves E Silva, Jaime Fernandes da Silva, Ana Carolina Lobor Cancelier, Daisson José Trevisol, Thiago Mamôru Sakae, Richard L Atkinson, Fabiana Schuelter Trevisol

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引用次数: 0

Abstract

Background: Previous studies have implicated human adenovirus 36 (Adv36) as a potential contributor to overweight and obesity. People living with HIV have an altered body composition compared to healthy individuals. There is still no evidence to confirm the relationship of Adv36 as one of the causes of lipohypertrophy. The main objective of this study was to verify the viral Adv36 infection as a factor associated with the presence of lipohypertrophy in HIV-infected individuals.

Methods: A case-control study on people with HIV treated at a specialized public health service in southern Brazil. Subjects underwent interviews, diagnostic tests, and anthropometry to determine lipodystrophy and its classification. Demographic and clinical data were examined to investigate the presence of Adv36. The cases were participants with lipohypertrophy, and the controls were eutrophic participants.

Results: 101 participants were included (38 cases and 63 controls), and the frequency of Adv36 infection was 10.9%. There was a statistically significant association between lipohypertrophy and the female sex (p < 0.001), and a trend for the presence of Adv36 (p = 0.059) and lipohypertrophy. After adjustment for confounders, Adv36 has not considered an independent risk factor for lipohypertrophy. Lower levels of glucose were associated with Adv36 infection.

Conclusion: There was a significant association between lipohypertrophy and the female sex, and no association with lipohypertrophy and Adv36, perhaps due to the small sample size.

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HIV感染者的腺病毒36合并感染及其对脂肪肥大的影响

背景:先前的研究表明人类腺病毒36 (Adv36)是超重和肥胖的潜在因素。与健康人相比，艾滋病毒感染者的身体组成发生了变化。目前还没有证据证实Adv36与脂肪肥大的关系。本研究的主要目的是验证病毒Adv36感染是否与hiv感染者中存在的脂肪肥大相关。方法:对在巴西南部一家专门公共卫生服务机构接受治疗的艾滋病毒感染者进行病例对照研究。研究对象通过访谈、诊断测试和人体测量来确定脂肪营养不良及其分类。通过人口统计学和临床资料调查Adv36的存在。这些病例是脂肪肥大的参与者，而对照组是富营养化的参与者。结果:共纳入101例(38例，63例对照)，Adv36感染发生率为10.9%。脂肪肥大与女性之间存在统计学意义上的相关性(p < 0.001)， Adv36的存在与脂肪肥大存在趋势(p = 0.059)。在调整混杂因素后，Adv36并未被认为是脂肪肥大的独立危险因素。较低的葡萄糖水平与Adv36感染有关。结论:脂肪肥大与女性有显著相关性，与脂肪肥大与Adv36无相关性，可能是样本量小所致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.