Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics Pub Date : 2023-10-01 DOI:10.1016/j.pacs.2023.100549

Juliana Benavides-Lara, Rayyan Manwar, Laura S. McGuire, Md. Tarikul Islam, Anthony Shoo, Fady T. Charbel, Martha G. Menchaca, Amanda P. Siegel, De-Ann M. Pillers, Juri G. Gelovani, Kamran Avanaki

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Abstract

Intraventricular (IVH) and periventricular (PVH) hemorrhages in preterm neonates are common because the periventricular blood vessels are still developing up to 36 weeks and are fragile. Currently, transfontanelle ultrasound (US) imaging is utilized for screening for IVH and PVH, largely through the anterior fontanelle. However for mild hemorrhages, inconclusive diagnoses are common, leading to failure to detect IVH/PVH or, when other clinical symptoms are present, use of second stage neuroimaging modalities requiring transport of vulnerable patients. Yet even mild IVH/PVH increases the risk of moderate-severe neurodevelopmental impairment. Here, we demonstrate the capability of transfontanelle photoacoustic imaging (TFPAI) to detect IVH and PVH in-vivo in a large animal model. TFPAI was able to detect IVH/PVH as small as 0.3 mL in volume in the brain (p < 0.05). By contrast, US was able to detect hemorrhages as small as 0.5 mL. These preliminary results suggest TFPAI could be translated into a portable bedside imaging probe for improved diagnosis of clinically relevant brain hemorrhages in neonates.

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活体绵羊脑室内脑出血的跨腔光声成像

早产儿的脑室内（IVH）和脑室周围（PVH）出血很常见，因为脑室周围血管在36周内仍在发育，而且很脆弱。目前，经囟门超声（US）成像主要通过前囟门用于IVH和PVH的筛查。然而，对于轻度出血，不确定的诊断很常见，导致无法检测IVH/PVH，或者当出现其他临床症状时，使用第二阶段神经成像模式需要运送易受感染的患者。然而，即使是轻微的IVH/PVH也会增加中重度神经发育障碍的风险。在这里，我们证明了转染体光声成像（TFPAI）在大型动物模型中检测体内IVH和PVH的能力。TFPAI能够检测到大脑中体积小至0.3mL的IVH/PVH（p＜0.05）。相比之下，US能够检测到体积小至0.5mL的出血。这些初步结果表明，TFPAI可以转化为便携式床边成像探针，用于改善新生儿临床相关脑出血的诊断。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.