Gastrointestinal System Involvement in Pediatric Patients with Acute SARS-CoV-2 Infection.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL

Medeniyet medical journal Pub Date : 2022-12-28 DOI:10.4274/MMJ.galenos.2022.79674

Ozlem Kalaycik Sengul, Burcin Beken, Zehra Ozturk, Seyma Ozpinar, Gizem Ozkan, Gizem Gungor

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引用次数: 1

Abstract

Objective: The prevalence of gastrointestinal symptoms in coronavirus disease-2019 (COVID-19) has been reported widely. In this study, the prevalence of gastrointestinal system (GIS) involvement in pediatric COVID-19 and its effect on prognosis were investigated.

Methods: Children (aged 0-18 years) with acute COVID-19 were included in the study. The patients were grouped according to system involvement: isolated respiratory system (RS), isolated GIS, and combination of both (RS+GIS). These groups were compared in terms of demographic data, clinical characteristics, laboratory and imaging findings, and hospitalization.

Results: A total of 223 pediatric patients were included in the study. Of these patients, 19 were asymptomatic, 12 were diagnosed with a multisystem inflammatory syndrome in children, 21 had chronic disorders that may affect disease severity, and 27 had symptoms not related to RS or GIS. The remaining 144 patients were classified according to system involvement: 79 (35.4%), 14 (6.3%), and 51 (22.9%) had isolated RS, isolated GIS, and RS+GIS involvement, respectively. The GIS group was much younger than the RS group (median, 30 and 150 months, respectively, p=0.006). Three patients from the RS group were followed in the intensive care unit (ICU). Moreover, 17 (21.5%) and 4 (7.8%) patients from the RS group had severe-critical respiratory symptoms, in the RS+GIS group had severe-critical respiratory symptoms (p=0.039).

Conclusions: Our study showed that GIS involvement in children with COVID-19 is more prevalent than RS involvement in the younger age group. Respiratory symptom severity and ICU admission also decreased with accompanying GIS involvement. GIS involvement was still associated with a milder disease course after adjustment for age.

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小儿急性SARS-CoV-2感染对胃肠道系统的影响

目的:新型冠状病毒病-2019 (COVID-19)患者胃肠道症状的患病率已被广泛报道。本研究旨在探讨小儿COVID-19中胃肠道系统(GIS)的患病率及其对预后的影响。方法:选取0 ~ 18岁急性COVID-19患儿为研究对象。根据系统累及情况分为:孤立呼吸系统(RS)、孤立呼吸系统(GIS)和两者合并(RS+GIS)。比较两组患者的人口学资料、临床特征、实验室和影像学检查结果以及住院情况。结果:共有223名儿童患者被纳入研究。在这些患者中，19名无症状，12名被诊断为儿童多系统炎症综合征，21名患有可能影响疾病严重程度的慢性疾病，27名患有与RS或GIS无关的症状。其余144例患者根据系统受累程度进行分类:分别有79例(35.4%)、14例(6.3%)和51例(22.9%)为孤立性RS、孤立性GIS和RS+GIS受累。GIS组比RS组年轻得多(中位数，30和150个月，分别p=0.006)。RS组3例患者在重症监护病房(ICU)随访。RS组有17例(21.5%)和4例(7.8%)患者出现严重危重性呼吸道症状，RS+GIS组有严重危重性呼吸道症状(p=0.039)。结论:我们的研究表明，在感染COVID-19的儿童中，GIS介入比RS介入更普遍。呼吸道症状严重程度和ICU住院率也随GIS的介入而降低。经年龄调整后，GIS介入仍与较轻的病程相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medeniyet medical journal Medicine-Medicine (all)

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

5 weeks

期刊介绍： The Medeniyet Medical Journal (Medeniyet Med J) is an open access, peer-reviewed, and scientific journal of Istanbul Medeniyet University Faculty of Medicine on various academic disciplines in medicine, which is published in English four times a year, in March, June, September, and December by a group of academics. Medeniyet Medical Journal is the continuation of Göztepe Medical Journal (ISSN: 1300-526X) which was started publishing in 1985. It changed the name as Medeniyet Medical Journal in 2015. Submission and publication are free of charge. No fees are asked from the authors for evaluation or publication process. All published articles are available online in the journal website (www.medeniyetmedicaljournal.org) without any fee. The journal publishes intradisciplinary or interdisciplinary clinical, experimental, and basic researches as well as original case reports, reviews, invited reviews, or letters to the editor, Being published since 1985, the Medeniyet Med J recognizes that the best science should lead to better lives based on the fact that the medicine should serve to the needs of society, and knowledge should transform society. The journal aims to address current issues at both national and international levels, start debates, and exert an influence on decision-makers all over the world by integrating science in everyday life. Medeniyet Med J is committed to serve the public and influence people’s lives in a positive way by making science widely accessible. Believing that the only goal is improving lives, and research has an impact on people’s lives, we select the best research papers in line with this goal.