Biomarkers of aging for the identification and evaluation of longevity interventions.

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2023-08-31 DOI:10.1016/j.cell.2023.08.003

Mahdi Moqri, Chiara Herzog, Jesse R Poganik, Jamie Justice, Daniel W Belsky, Albert Higgins-Chen, Alexey Moskalev, Georg Fuellen, Alan A Cohen, Ivan Bautmans, Martin Widschwendter, Jingzhong Ding, Alexander Fleming, Joan Mannick, Jing-Dong Jackie Han, Alex Zhavoronkov, Nir Barzilai, Matt Kaeberlein, Steven Cummings, Brian K Kennedy, Luigi Ferrucci, Steve Horvath, Eric Verdin, Andrea B Maier, Michael P Snyder, Vittorio Sebastiano, Vadim N Gladyshev

{"title":"Biomarkers of aging for the identification and evaluation of longevity interventions.","authors":"Mahdi Moqri, Chiara Herzog, Jesse R Poganik, Jamie Justice, Daniel W Belsky, Albert Higgins-Chen, Alexey Moskalev, Georg Fuellen, Alan A Cohen, Ivan Bautmans, Martin Widschwendter, Jingzhong Ding, Alexander Fleming, Joan Mannick, Jing-Dong Jackie Han, Alex Zhavoronkov, Nir Barzilai, Matt Kaeberlein, Steven Cummings, Brian K Kennedy, Luigi Ferrucci, Steve Horvath, Eric Verdin, Andrea B Maier, Michael P Snyder, Vittorio Sebastiano, Vadim N Gladyshev","doi":"10.1016/j.cell.2023.08.003","DOIUrl":null,"url":null,"abstract":"<p><p>With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":"186 18","pages":"3758-3775"},"PeriodicalIF":45.5000,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11088934/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.cell.2023.08.003","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.

查看原文本刊更多论文

用于识别和评估长寿干预措施的衰老生物标志物。

随着衰老生物学研究的迅速发展，确定和评估人类长寿干预措施已成为该领域的关键目标。衰老生物标志物是在现实时间框架内实现这些目标的重要工具。然而，目前对可靠的衰老生物标志物的特性缺乏标准和共识，这阻碍了它们在临床应用中的进一步发展和验证。在此，我们提出了一个老化生物标志物的术语和表征框架，包括分类和潜在的临床用例。我们讨论了验证步骤，并强调了作为未来研究潜在领域的持续挑战。该框架为开发有效的老化生物标志物以及最终将其用于临床试验和实践奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.