Corneal damage threshold induced by supercontinuum source: A further study

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2023-09-01 DOI:10.1002/lsm.23722

Luguang Jiao PhD, Chao Wang MSc, Jiarui Wang PhD, Zaifu Yang PhD

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Abstract

Objectives

Previous report shows that corneal spot size is an important influence factor on damage threshold induced by supercontinumm (SC) source. However, damage thresholds were determined for the spot size of only 0.37 mm due to the low output of the employed SC source at that time. The objectives of this study are to determine the lowest possible corneal damage threshold at a large corneal spot size using a more powerful SC source and provide data for the future possible refinements of laser safety standards.

Materials and Methods

A series of experiments was conducted in the New Zealand white rabbit model to determine the corneal damage threshold induced by a 900–2000 nm SC source, with corneal 1/e beam diameter of about 1.2 mm. Slit-lamp biomicroscope was employed to reveal the corneal damage characteristics. By employing the action spectra determined through the analysis of current laser safety guidelines and standards, the effective damage threshold could be calculated.

Results

The determined damage threshold given in terms of the peak radiant exposure for the exposure duration of 0.14 s was 44.3 J/cm². At threshold level, corneal damages involved the epithelium and the shallower stroma. The safety factor between the effective damage threshold and the corresponding maximum permissible exposure (MPE) was about 45.

Conclusions

Present corneal MPEs in the wavelength range of 700–1200 nm may be conservative and corneal damage thresholds for the infrared A wavelengths should be determined in future studies.

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超连续谱源引起角膜损伤阈值的进一步研究。

目的：已有研究表明，角膜斑点大小是影响超连续辐射源损伤阈值的重要因素。然而，确定的损伤阈值仅为0.37 mm，这是由于当时所使用的SC源的低输出。本研究的目的是使用更强大的SC源确定大角膜斑点尺寸下可能的最低角膜损伤阈值，并为未来可能的激光安全标准改进提供数据。材料和方法：在新西兰大白鼠模型中进行了一系列实验，以确定900-2000 nm SC源，角膜1/e光束直径约为1.2 采用裂隙灯生物显微镜观察角膜损伤特点。通过分析现行激光安全指南和标准确定的作用光谱，可以计算有效损伤阈值。结果：根据暴露持续时间0.14的峰值辐射暴露，确定的损伤阈值 s为44.3 J/cm2。在阈值水平上，角膜损伤涉及上皮和较浅的基质。有效损伤阈值和相应的最大允许暴露量（MPE）之间的安全系数约为45。结论：目前角膜MPEs的波长范围为700-1200 nm可能是保守的，红外A波长的角膜损伤阈值应在未来的研究中确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.

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