A diagnostic biomarker of acid glycoprotein 1 for distinguishing malignant from benign pulmonary lesions.

IF 2.3 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

International Journal of Biological Markers Pub Date : 2023-12-01 Epub Date: 2023-09-01 DOI:10.1177/03936155231192672

Ying Chen, Yueyang Zhang, Ankang Huang, Yongsheng Gong, Weidong Wang, Jicheng Pan, Yanxia Jin

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引用次数: 0

Abstract

Background: The acid glycoprotein 1 (AGP1) is downregulated in lung cancer. However, the performance of AGP1 in distinguishing benign from malignant lung lesions is still unknown.

Methods: The expression of AGP1 in benign diseases and lung cancer samples was detected by Western blot. The receiver operating characteristic curves, bivariate correlation, and multivariate analysis was analyzed by SPSS software.

Results: AGP1 expression levels were significantly downregulated in lung cancer and correlated with carcinoembryonic antigen (CEA), CA199, and CA724 tumor biomarkers. The diagnostic performance of AGP1 for distinguishing malignant from benign pulmonary lesions was better than the other four clinical biomarkers including CEA, squamous cell carcinoma-associated antigen, neuron-specific enolase, and cytokeratin 19 fragment 21-1, with an area under the curve value of 0.713 at 88.8% sensitivity. Furthermore, the multivariate analysis indicated that the variates of thrombin time and potassium significantly affected the AGP1 levels in lung cancer.

Conclusions: Our study indicates that AGP1 expression is decreased in lung cancer compared to benign samples, which helps distinguish benign and malignant pulmonary lesions.

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用于区分肺部恶性和良性病变的酸性糖蛋白 1 诊断生物标志物。

背景：酸性糖蛋白1（AGP1）在肺癌中呈下调趋势。然而，AGP1 在区分肺部良性和恶性病变方面的作用尚不清楚：方法：采用 Western 印迹法检测 AGP1 在良性疾病和肺癌样本中的表达。结果：AGP1在良性疾病和肺癌样本中的表达水平显著下降，而在恶性疾病中的表达水平则显著升高：结果：AGP1在肺癌中的表达水平明显下调，并与癌胚抗原（CEA）、CA199和CA724等肿瘤生物标志物相关。在区分肺部恶性和良性病变方面，AGP1的诊断性能优于其他四种临床生物标志物，包括癌胚抗原、鳞状细胞癌相关抗原、神经元特异性烯醇化酶和细胞角蛋白19片段21-1，其曲线下面积值为0.713，敏感性为88.8%。此外，多变量分析表明，凝血酶时间和血钾等变量对肺癌患者的 AGP1 水平有显著影响：我们的研究表明，与良性样本相比，AGP1在肺癌中的表达降低，这有助于区分肺部良性和恶性病变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Biological Markers 医学-生物工程与应用微生物

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.