Variations in the TAS2R38 gene among college students in Hubei.

IF 2.7 3区生物学

Hereditas Pub Date : 2022-12-19 DOI:10.1186/s41065-022-00260-x

Xiaojun Wang, Lin Wang, Mengwei Xia, Feng Teng, Xuejiao Chen, Rufeng Huang, Jiahao Zhou, Juan Xiao, Lihong Zhai

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Abstract

Background: The bitter taste receptor gene TAS2R38 is a member of the human TAS2R gene family. Polymorphisms in TAS2R38 affect the ability to taste the bitterness of phenylthiourea (PTC) compounds, thus affecting an individual's food preference and health status.

Methods: We investigated polymorphisms in the TAS2R38 gene and the sensitivity to PTC bitterness among healthy Chinese college students in Hubei province. The association of TAS2R38 polymorphisms and PTC sensitivity with body mass index (BMI), food preference, and health status was also analyzed. A total of 320 healthy college students were enrolled (male: 133, female: 187; aged 18-23 years). The threshold value method was used to measure the perception of PTC bitterness, and a questionnaire was used to analyze dietary preferences and health status. Polymerase chain reaction (PCR) was used to analyze polymorphisms at three common TAS2R38 loci (rs713598, rs1726866, and rs10246939).

Results: In our study population, 65.00% of individuals had medium sensitivity to the bitterness of PTC; in contrast, 20.94% were highly sensitive to PTC bitterness, and 14.06% were not sensitive. For the TAS2R38 gene, the PAV/PAV and PAV/AAI diplotypes were the most common (42.19% and 40.63%, respectively), followed by the homozygous AVI/AVI (8.75%) and PAV/AVI (5.00%) diplotypes.

Conclusion: There was a significant correlation between the sensitivity to PTC bitterness and sex, but there was no correlation between the common diplotypes of TAS2R38 and gender. Polymorphisms in the TAS2R38 gene were associated with the preference for tea, but not with one's native place, BMI, health status, or other dietary preferences. There was no significant correlation between the perception of PTC bitterness and one's native place, BMI, dietary preference, or health status. We hope to find out the relationship between PTC sensitivity and TAS2R38 gene polymorphisms and dietary preference and health status of Chinese population through this study, providing relevant guidance and suggestions for dietary guidance and prevention of some chronic diseases in Chinese population.

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湖北大学生TAS2R38基因变异

背景:苦味受体基因TAS2R38是人类TAS2R基因家族的一员。TAS2R38基因的多态性会影响对苯硫脲(PTC)化合物苦味的品尝能力，从而影响个体的食物偏好和健康状况。方法:对湖北省健康大学生TAS2R38基因多态性及对PTC苦味的敏感性进行研究。研究还分析了TAS2R38多态性和PTC敏感性与体重指数(BMI)、食物偏好和健康状况的关系。共招募健康大学生320人(男133人，女187人;18-23岁)。采用阈值法测量受试者对PTC苦味的感知，采用问卷调查分析饮食偏好和健康状况。聚合酶链反应(PCR)分析了TAS2R38三个常见位点(rs713598、rs1726866和rs10246939)的多态性。结果:在我们的研究人群中，65.00%的个体对PTC苦味具有中等敏感性;对PTC苦味高度敏感的占20.94%，不敏感的占14.06%。TAS2R38基因以PAV/PAV和PAV/AAI二倍型最多(分别为42.19%和40.63%)，其次是纯合子AVI/AVI(8.75%)和PAV/AVI(5.00%)。结论:PTC苦味敏感性与性别有显著相关性，而TAS2R38常见二倍型与性别无相关性。TAS2R38基因的多态性与对茶的偏好有关，但与一个人的出生地、体重指数、健康状况或其他饮食偏好无关。PTC苦味感知与一个人的出生地、BMI、饮食偏好或健康状况之间没有显著相关性。我们希望通过本研究发现PTC敏感性与TAS2R38基因多态性与中国人群饮食偏好和健康状况之间的关系，为中国人群饮食指导和部分慢性疾病的预防提供相关的指导和建议。

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来源期刊

Hereditas Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.80

自引率

3.70%

发文量

期刊介绍： For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.