Impact of aerobic fitness status, menstrual cycle phase, and oral contraceptive use on exercise substrate oxidation and metabolic flexibility in females.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-01-01 Epub Date: 2023-09-01 DOI:10.1139/apnm-2023-0101
Alyssa A Olenick, Regis C Pearson, Nathan T Jenkins
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Abstract

The influence of menstrual cycle phase and fitness status on metabolism during high-intensity interval exercise (HIIE) was assessed. Twenty-five females (24.4 (3.6) years) were categorized by normal menstrual cycle (n = 14) vs. oral contraceptive (OC) use (n = 11) and by aerobic fitness, high-fitness females (HFF; n = 13) vs. low-fitness females (LFF; n = 12). HIIE was four sets of four repetitions with a 3 min rest between intervals on a cycle ergometer at a power output halfway between the ventilatory threshold and V̇O2peak and performed during follicular (FOL: days 2-7 or inactive pills) and luteal phases (LUT: day ∼21 or 3rd week of active pills). Substrate oxidation was assessed via indirect calorimetry, blood lactate via finger stick, and recovery of skeletal muscle oxidative metabolism (mV̇O2) via continuous-wave near-infrared spectroscopy. HFF oxidized more fat (g·kg-1) during the full session (FOL: p = 0.050, LUT: p = 0.001), high intervals (FOL: p = 0.048, LUT: p = 0.001), low intervals (FOL: p = 0.032, LUT: p = 0.024), and LUT recovery (p = 0.033). Carbohydrate oxidation area under the curve was greater in HFF during FOL (FOL: p = 0.049, LUT: p = 0.124). Blood lactate was lower in LFF in FOL (p ≤ 0.05) but not in LUT. Metabolic flexibility (Δ fat oxidation g·kg-1·min-1) was greater in HFF than LFF during intervals 2-3 in FOL and 1-4 in LUT (p ≤ 0.05). Fitness status more positively influences exercise metabolic flexibility during HIIE than cycle phase or OC use.

有氧健身状态、月经周期阶段和口服避孕药对女性运动基质氧化和代谢灵活性的影响。
评估了高强度间歇运动(HIIE)期间月经周期阶段和体能状况对代谢的影响。25名女性(24.4(3.6)岁)按正常月经周期(n=14)与口服避孕药(OC)使用(n=11)以及有氧健身、高健身女性(HFF;n=13)与低健身女性(LFF;n=12)进行分类。HIIE是四组四次重复,间隔3分钟在循环测力计上休息,功率输出在通气阈值和V̇O2峰值之间,在卵泡期(FOL:第2-7天或非活性药丸)和黄体期(LUT:第~21天或活性药丸第3周)进行。通过间接量热法评估底物氧化,通过手指棒评估血液乳酸,通过连续波近红外光谱评估骨骼肌氧化代谢(mV̇O2)的恢复。HFF在整个疗程中氧化更多的脂肪(g·kg-1)(FOL:p=0.050,LUT:p=0.001),高间隔(FOL:p=0.048,LUT:p=0.001),低间隔(FOL:p=0.032,LUT:0.024),和LUT恢复(p=0.033)。在FOL期间,HFF曲线下的碳水化合物氧化面积较大(FOL:p=0.049,LUT:p=0.124)。血液乳酸在FOL中LFF较低(p≤0.05),但在LUT中没有。在FOL的间隔2-3和LUT的间隔1-4期间,HFF的代谢灵活性(Δ脂肪氧化g·kg-1·min-1)大于LFF(p≤0.05)。在HIIE期间,健身状态对运动代谢灵活性的影响比周期期或OC使用更积极。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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