Association of Peritoneal Cytology with Other Prognostic Factors in Endometrial Cancer.

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Journal of Cytology Pub Date : 2022-10-01 Epub Date: 2022-10-28 DOI:10.4103/joc.joc_53_22

Slobodan Maricic, Aljosa Mandic, Tijana Vasiljević, Bojana Gutic, Nemanja Stevanovic, Tamara Maksimovic

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引用次数: 2

Abstract

Purpose: It is still debatable whether surgical staging of endometrial cancer (EC) should include sampling of peritoneal cytology (PC) and for what purpose this should be done. The aim of our study was to determine the significance of peritoneal cytology in EC and its association with other histological and clinical parameters.

Methods: This is a retrospective study that comprises of results from 357 patients with EC that were operated in our center in the previous nine years. Patients were divided into two groups: the first group with a positive and the second group with a negative PC.

Results: Malignant cells were found in the peritoneal cytology of 23 patients (6.4%), while 334 patients (93.6%) had negative PC. There was no significant difference in patients' age between the two groups (p = 0.20). Peritoneal cytology was more prevalent in the non-endometrioid than the endometrioid subtype of EC (p = 0.00). There was a significant statistical difference (p = 0.00) in malignant PC in stages where cancer is confined to the uterus (International Federation of Gynecologists and Obstetricians (FIGO) stages I and II) compared with those where cancer has metastasized outside the uterus (stages III and IV). Most of the patients with malignant PC (69.6%) had high-grade disease (G3).

Conclusion: Malignant peritoneal cytology is associated with other negative prognostic factors in endometrial cancer (histological grade, FIGO stage, and non-endometrioid histological subtypes). Based on these findings, we encourage sampling of peritoneal washing in all EC patients and consider it mandatory in patients with non-endometrioid subtype, high-grade histology, and in advanced FIGO stage.

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癌症子宫内膜细胞学与其他预后因素的相关性。

目的：癌症（EC）的手术分期是否应包括腹膜细胞学检查（PC）以及检查的目的仍然存在争议。我们研究的目的是确定腹膜细胞学在EC中的意义及其与其他组织学和临床参数的关系。方法：这是一项回顾性研究，包括过去九年在我们中心手术的357名EC患者的结果。将患者分为两组：第一组PC阳性，第二组PC阴性。结果：腹膜细胞学检查发现恶性细胞23例（6.4%），PC阴性334例（93.6%）。两组患者的年龄无显著差异（p=0.20）。腹膜细胞学检查在非子宫内膜样病变中比EC的子宫内膜样亚型更普遍（p=0.00）。在癌症局限于子宫的阶段，恶性PC有显著的统计学差异（p＝0.00）（国际妇产科联合会（FIGO）I期和II）与癌症转移到子宫外的那些相比（III和IV期）。结论：恶性腹膜细胞学检查与癌症的其他不良预后因素（组织学分级、FIGO分期和非子宫内膜样组织学亚型）有关。基于这些发现，我们鼓励对所有EC患者进行腹膜冲洗取样，并认为非子宫内膜样亚型、高级别组织学和晚期FIGO阶段的患者必须进行腹膜冲洗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cytology MEDICAL LABORATORY TECHNOLOGY-

CiteScore

1.80

自引率

7.70%

发文量

审稿时长

46 weeks

期刊介绍： The Journal of Cytology is the official Quarterly publication of the Indian Academy of Cytologists. It is in the 25th year of publication in the year 2008. The journal covers all aspects of diagnostic cytology, including fine needle aspiration cytology, gynecological and non-gynecological cytology. Articles on ancillary techniques, like cytochemistry, immunocytochemistry, electron microscopy, molecular cytopathology, as applied to cytological material are also welcome. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews, meta-analysis, and debates.