How Molecular Discoveries Have Changed Liver Tumor Pathology: A Brief Review.

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Negar Taheri, Rondell P Graham
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引用次数: 0

Abstract

Context: Recent molecular discoveries have led to improved understanding of tumor biology and the development of new diagnostic assays.

Objective: To review primarily 3 examples of liver tumors and to briefly illustrate how recent molecular discoveries have altered clinical liver pathology practice.

Data sources: First, we will discuss fibrolamellar carcinoma, which will be the main focus of discussion, as an example for new diagnostic tests that have been developed as a result of molecular discoveries. Additional information on the role of molecular diagnostics in hepatocellular adenoma and hepatocellular carcinoma will be provided. Second, we will use the example of epithelioid hemangioendothelioma as an example of how new diagnostic tools, based on molecular discoveries, may support improved prognostication. Finally, we will use the example of intrahepatic cholangiocarcinoma as an example of a liver tumor where new molecular discoveries have identified tractable therapeutic targets and led to new effective therapies. This portion of the manuscript will also include a description of the anatomic and molecular differences between intrahepatic, hilar, and extrahepatic cholangiocarcinoma.

Conclusions: Fueled by molecular discoveries, new and better diagnostic tests and therapeutic targets have improved clinical care in patients affected by liver tumors.

分子发现如何改变肝脏肿瘤病理学?简要回顾。
背景:最近的分子发现提高了人们对肿瘤生物学的认识,并开发了新的诊断方法:主要回顾 3 个肝脏肿瘤实例,简要说明最新的分子发现如何改变了临床肝脏病理学实践:首先,我们将讨论纤维母细胞瘤,这将是讨论的重点,并以此为例说明由于分子发现而开发的新诊断检测方法。我们还将提供有关分子诊断在肝细胞腺瘤和肝细胞癌中的作用的补充信息。其次,我们将以上皮样血管内皮细胞瘤为例,说明基于分子发现的新诊断工具如何有助于改善预后。最后,我们将以肝内胆管癌为例,说明在肝脏肿瘤中,新的分子发现发现了可治疗的靶点,并带来了新的有效疗法。手稿的这一部分还将包括对肝内胆管癌、肝门胆管癌和肝外胆管癌之间的解剖和分子差异的描述:在分子发现的推动下,新的、更好的诊断测试和治疗目标改善了肝肿瘤患者的临床治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
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