Newly recognised Tumour Types in Glioneuronal tumours according to the 5th edition of the CNS WHO Classification.

IF 4.4 Q1 PATHOLOGY
PATHOLOGICA Pub Date : 2022-12-01 DOI:10.32074/1591-951X-819
Valeria Barresi, Francesca Gianno, Gianluca Marucci
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引用次数: 2

Abstract

Glioneuronal tumours (GNT) are uncommon neoplasms, characterised by glial and neuronal differentiation.

In the 5th edition of the World Health Organization (WHO) Classification, they are grouped under the heading "Glioneuronal and neuronal tumours", which comprises fourteen different tumours, among which the diffuse glioneuronal tumour with oligodendroglioma-like cells and nuclear clusters (DGONC), myxoyd glioneuronal tumour (MGT) and multinodular and vacuolating neuronal tumour (MNVNT) are new types.

MGT and MNVNT are classified WHO grade 1 and may be recognised and diagnosed by peculiar clinical-pathological features. DGONC was not assigned a WHO grade and was only provisionally included among GNT, due to the possibility that it rather represents an embryonal tumour type or subtype. Although the histopathological characteristics may be useful for its identification, the specific methylation profile is an essential diagnostic criterion for DGONC.

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Abstract Image

根据CNS世界卫生组织分类第5版新发现的胶质神经元肿瘤类型。
神经胶质细胞肿瘤(GNT)是一种罕见的肿瘤,以胶质细胞和神经元分化为特征。在世界卫生组织(世卫组织)第5版分类中,它们被归类在“胶质细胞和神经元肿瘤”的标题下,其中包括14种不同的肿瘤,其中具有少突胶质细胞瘤样细胞和核簇的弥漫性胶质细胞肿瘤(DGONC)、黏液性胶质细胞肿瘤(MGT)和多结节和空泡性神经元肿瘤(MNVNT)是新类型。MGT和MNVNT被WHO列为1级,可通过特殊的临床病理特征来识别和诊断。由于DGONC可能代表一种胚胎肿瘤类型或亚型,因此未给WHO分级,也只是暂时纳入GNT。虽然组织病理学特征可能有助于其鉴定,但特异性甲基化谱是DGONC的基本诊断标准。
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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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