Notch Signalling Under Maternal-to-Zygotic Transition.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Fly Pub Date : 2022-12-01 DOI:10.1080/19336934.2022.2139981

Tomoko Yamakawa, Elzava Yuslimatin Mujizah, Kenji Matsuno

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引用次数: 1

Abstract

The development of all animal embryos is initially directed by the gene products supplied by their mothers. With the progression of embryogenesis, the embryo's genome is activated to command subsequent developments. This transition, which has been studied in many model animals, is referred to as the Maternal-to-Zygotic Transition (MZT). In many organisms, including flies, nematodes, and sea urchins, genes involved in Notch signaling are extensively influenced by the MZT. This signaling pathway is highly conserved across metazoans; moreover, it regulates various developmental processes. Notch signaling defects are commonly associated with various human diseases. The maternal contribution of its factors was first discovered in flies. Subsequently, several genes were identified from mutant embryos with a phenotype similar to Notch mutants only upon the removal of the maternal contributions. Studies on these maternal genes have revealed various novel steps in the cascade of Notch signal transduction. Among these genes, pecanex and almondex have been functionally characterized in recent studies. Therefore, in this review, we will focus on the roles of these two maternal genes in Notch signaling and discuss future research directions on its maternal function.

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母系转合子过程中的Notch信号传导。

所有动物胚胎的发育最初都是由母体提供的基因产物指导的。随着胚胎发生的进展，胚胎的基因组被激活以指挥后续的发育。这种转变，已经在许多模型动物中进行了研究，被称为母系到受精卵的转变(MZT)。在包括苍蝇、线虫和海胆在内的许多生物中，Notch信号的相关基因受到MZT的广泛影响。这种信号通路在后生动物中高度保守;此外，它还调节各种发育过程。Notch信号缺陷通常与各种人类疾病有关。母体对其因子的贡献首先在果蝇中被发现。随后，从突变胚胎中鉴定出几个基因，仅在去除母系贡献后，其表型与Notch突变相似。对这些母系基因的研究揭示了Notch信号转导级联中的各种新步骤。在这些基因中，pecanex和almondex在最近的研究中得到了功能表征。因此，在本文中，我们将重点介绍这两个母系基因在Notch信号传导中的作用，并讨论其母系功能的未来研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fly 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Fly is the first international peer-reviewed journal to focus on Drosophila research. Fly covers a broad range of biological sub-disciplines, ranging from developmental biology and organogenesis to sensory neurobiology, circadian rhythm and learning and memory, to sex determination, evolutionary biology and speciation. We strive to become the “to go” resource for every researcher working with Drosophila by providing a forum where the specific interests of the Drosophila community can be discussed. With the advance of molecular technologies that enable researchers to manipulate genes and their functions in many other organisms, Fly is now also publishing papers that use other insect model systems used to investigate important biological questions. Fly offers a variety of papers, including Original Research Articles, Methods and Technical Advances, Brief Communications, Reviews and Meeting Reports. In addition, Fly also features two unconventional types of contributions, Counterpoints and Extra View articles. Counterpoints are opinion pieces that critically discuss controversial papers questioning current paradigms, whether justified or not. Extra View articles, which generally are solicited by Fly editors, provide authors of important forthcoming papers published elsewhere an opportunity to expand on their original findings and discuss the broader impact of their discovery. Extra View authors are strongly encouraged to complement their published observations with additional data not included in the original paper or acquired subsequently.