Sex differences in ¹²³I-mIBG scintigraphy imaging techniques in patients with heart failure.

IF 2.9 3区医学 Q3 ENGINEERING, BIOMEDICAL

Expert Review of Medical Devices Pub Date : 2023-07-01 Epub Date: 2023-07-24 DOI:10.1080/17434440.2023.2239139

Miriam Conte, Maria Silvia De Feo, Viviana Frantellizzi, Arianna Di Rocco, Alessio Farcomeni, Flaminia De Cristofaro, Ricci Maria, Antonio Rosario Pisani, Giuseppe Rubini, Giuseppe De Vincentis

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引用次数: 0

Abstract

Background: ¹²³I-mIBG-scintigraphy could be a useful stratifying tool for patients with heart failure (HF). The purpose of this retrospective study is to evaluate whether there are differences between men and women with HF in terms of the prediction of cardiac arrhythmic events (AE).

Research and methods: A total of 306 patients, before implantable-cardioverter-defibrillator (ICD) implantation, were evaluated. They underwent ¹²³I-mIBG-scintigraphy and an evaluation of the results was performed after 85 months of follow-up. Early and late planar and SPECT cardiac images were acquired. Heart-to-mediastinum ratio (HM) for planar images and the sum of the segmental scores (SS) for SPECT were calculated.

Results: In the general population, age, early SS (ESS), late SS (LSS), and ejection fraction (EF) were statistically significant for the prediction of AE at Cox regression, while early and late HM (eHM,lHM) were not significative for the prediction of AE. Population was divided into females and males and univariate analysis was conducted separately for the two cohorts: no significant variables for prediction of AE were found in females. For males, ESS, LSS, EF, and late HM were statistically significant predictors of AE. The overall survival was similar in males and females, but the risk of AE is lower in males than in females.

Conclusions: ¹²³I-mIBG represents a more effective tool for the prediction of AE in male patients than in women.

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心力衰竭患者123I-mIBG闪烁成像技术的性别差异。

背景：123I mIBG闪烁显像可能是心力衰竭（HF）患者的一种有用的分层工具。本回顾性研究的目的是评估男性和女性HF患者在预测心律失常事件（AE）方面是否存在差异。研究和方法：在植入心律转复除颤器（ICD）之前，共对306名患者进行了评估。他们接受了123I mIBG闪烁扫描，并在85岁后对结果进行了评估随访数月。采集早期和晚期平面和SPECT心脏图像。计算平面图像的心纵隔比（HM）和SPECT的节段评分之和（SS）。结果：在一般人群中，年龄、早期SS（ESS）、晚期SS（LSS）和射血分数（EF）在Cox回归预测AE方面具有统计学意义，而早期和晚期HM（eHM，lHM）对预测AE没有统计学意义。将人群分为女性和男性，并分别对两个队列进行单变量分析：在女性中未发现预测AE的显著变量。对于男性，ESS、LSS、EF和晚期HM是AE的统计学显著预测因素。男性和女性的总生存率相似，但男性发生AE的风险低于女性。结论：123I-mIBG是预测男性患者AE的一种比女性患者更有效的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Medical Devices 医学-工程：生物医学

CiteScore

5.90

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal serves the device research community by providing a comprehensive body of high-quality information from leading experts, all subject to rigorous peer review. The Expert Review format is specially structured to optimize the value of the information to reader. Comprehensive coverage by each author in a key area of research or clinical practice is augmented by the following sections: Expert commentary - a personal view on the most effective or promising strategies Five-year view - a clear perspective of future prospects within a realistic timescale Key issues - an executive summary cutting to the author''s most critical points In addition to the Review program, each issue also features Medical Device Profiles - objective assessments of specific devices in development or clinical use to help inform clinical practice. There are also Perspectives - overviews highlighting areas of current debate and controversy, together with reports from the conference scene and invited Editorials.