Dynamic movement and turnover of extracellular matrices during tissue development and maintenance.

IF 2.4 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Fly Pub Date : 2022-12-01 DOI:10.1080/19336934.2022.2076539
Yutaka Matsubayashi
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引用次数: 0

Abstract

Extracellular matrices (ECMs) are essential for the architecture and function of animal tissues. ECMs have been thought to be highly stable structures; however, too much stability of ECMs would hamper tissue remodelling required for organ development and maintenance. Regarding this conundrum, this article reviews multiple lines of evidence that ECMs are in fact rapidly moving and replacing components in diverse organisms including hydra, worms, flies, and vertebrates. Also discussed are how cells behave on/in such dynamic ECMs, how ECM dynamics contributes to embryogenesis and adult tissue homoeostasis, and what molecular mechanisms exist behind the dynamics. In addition, it is highlighted how cutting-edge technologies such as genome engineering, live imaging, and mathematical modelling have contributed to reveal the previously invisible dynamics of ECMs. The idea that ECMs are unchanging is to be changed, and ECM dynamics is emerging as a hitherto unrecognized critical factor for tissue development and maintenance.

Abstract Image

Abstract Image

Abstract Image

细胞外基质在组织发育和维持过程中的动态运动和周转。
细胞外基质(ECM)对动物组织的结构和功能至关重要。ECM被认为是高度稳定的结构;然而,ECMs过于稳定会阻碍器官发育和维持所需的组织重塑。关于这个难题,本文回顾了多条证据,证明ECMs实际上正在迅速移动并取代包括水螅、蠕虫、苍蝇和脊椎动物在内的多种生物中的成分。还讨论了细胞在这种动态ECM上/中的行为,ECM动力学如何促进胚胎发生和成体组织稳态,以及动力学背后存在什么分子机制。此外,还强调了基因组工程、实时成像和数学建模等尖端技术如何有助于揭示ECMs以前看不见的动力学。ECM是不变的这一观点有待改变,ECM动力学正成为迄今为止尚未认识到的组织发育和维持的关键因素。
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来源期刊
Fly
Fly 生物-生化与分子生物学
CiteScore
2.90
自引率
0.00%
发文量
17
审稿时长
>12 weeks
期刊介绍: Fly is the first international peer-reviewed journal to focus on Drosophila research. Fly covers a broad range of biological sub-disciplines, ranging from developmental biology and organogenesis to sensory neurobiology, circadian rhythm and learning and memory, to sex determination, evolutionary biology and speciation. We strive to become the “to go” resource for every researcher working with Drosophila by providing a forum where the specific interests of the Drosophila community can be discussed. With the advance of molecular technologies that enable researchers to manipulate genes and their functions in many other organisms, Fly is now also publishing papers that use other insect model systems used to investigate important biological questions. Fly offers a variety of papers, including Original Research Articles, Methods and Technical Advances, Brief Communications, Reviews and Meeting Reports. In addition, Fly also features two unconventional types of contributions, Counterpoints and Extra View articles. Counterpoints are opinion pieces that critically discuss controversial papers questioning current paradigms, whether justified or not. Extra View articles, which generally are solicited by Fly editors, provide authors of important forthcoming papers published elsewhere an opportunity to expand on their original findings and discuss the broader impact of their discovery. Extra View authors are strongly encouraged to complement their published observations with additional data not included in the original paper or acquired subsequently.
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