PET and SPECT Imaging of ALS: An Educational Review.

IF 2.2 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Molecular Imaging Pub Date : 2023-08-19 eCollection Date: 2023-01-01 DOI:10.1155/2023/5864391

Ayaan M Jamali, Manasa Kethamreddy, Brian J Burkett, John D Port, Mukesh K Pandey

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Abstract

Amyotrophic lateral sclerosis (ALS) is a disease leading to progressive motor degeneration and ultimately death. It is a complex disease that can take a significantly long time to be diagnosed, as other similar pathological conditions must be ruled out for a definite diagnosis of ALS. Noninvasive imaging of ALS has shed light on disease pathology and altered biochemistry in the ALS brain. Other than magnetic resonance imaging (MRI), two types of functional imaging, positron emission tomography (PET) and single photon emission computed tomography (SPECT), have provided valuable data about what happens in the brain of ALS patients compared to healthy controls. PET imaging has revealed a specific pattern of brain metabolism through [¹⁸F]FDG, while other radiotracers have uncovered neuroinflammation, changes in neuronal density, and protein aggregation. SPECT imaging has shown a general decrease in regional cerebral blood flow (rCBF) in ALS patients. This educational review summarizes the current state of ALS imaging with various PET and SPECT radiopharmaceuticals to better understand the pathophysiology of ALS.

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ALS的PET和SPECT成像：教育综述。

肌萎缩侧索硬化症（ALS）是一种导致进行性运动变性并最终死亡的疾病。这是一种复杂的疾病，可能需要很长时间才能诊断出来，因为必须排除其他类似的病理状况才能明确诊断为ALS。ALS的无创成像揭示了ALS大脑中的疾病病理学和生物化学变化。除了磁共振成像（MRI），两种类型的功能成像，正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT），提供了关于ALS患者与健康对照组相比大脑中发生了什么的有价值的数据。PET成像揭示了通过[18F]FDG的大脑代谢的特定模式，而其他放射性示踪剂则揭示了神经炎症、神经元密度变化和蛋白质聚集。SPECT成像显示ALS患者的局部脑血流量（rCBF）普遍下降。这篇教育综述总结了各种PET和SPECT放射性药物对ALS成像的现状，以更好地了解ALS的病理生理学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology

自引率

3.60%

发文量

期刊介绍： Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.