Descriptive analysis of haemangiosarcoma occurrence in dogs enrolled in the Golden Retriever lifetime study.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Veterinary and comparative oncology Pub Date : 2023-12-01 Epub Date: 2023-08-27 DOI:10.1111/vco.12933
Alison Hillman, Brenna Swafford, Camille Delavenne, Hille Fieten, Kim Boerkamp, Kathy Tietje
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Abstract

Haemangiosarcoma is a relatively common malignant tumour in dogs, and one of the primary outcomes of interest for the Golden Retriever Lifetime Study. This study collects longitudinal data and samples from a cohort of golden retrievers, with the aim of identification of nutritional, genetic, environmental, lifestyle and reproductive risk factors for cancers and other important diseases in dogs. This analysis describes the accumulating data and samples, which are available for use by researchers to fulfil the study's objectives. As of September 2022, 233/3044 dogs enrolled in the study had been diagnosed with haemangiosarcoma (7.65%), with an incidence rate of 1.10 cases per 100 dog-years. Visceral haemangiosarcoma was the most common, affecting 211/3044 study dogs (6.9%). One hundred and twenty eight visceral haemangiosarcoma diagnoses specified the presence of splenic tumours (60.7%) and 119 specified the presence of cardiac tumours (56.4%). The probability of remaining without a haemangiosarcoma diagnosis declined from 100% from approximately 4 years of age, to a 12 year probability of 91.1% in intact females (95% CI 84.4%-98.3%), 60.7% in neutered females (95% CI 41.6%-88.6%), 72.9% in intact males (95% CI 62.9%-84.6%) and 70.0% in neutered males (95% CI 53.4%-92.0%). The 1 year survival probability for visceral haemangiosarcoma was 1.42% (95% CI 0.37%-5.47%); for cutaneous haemangiosarcoma, it was 84.6% (95% CI 67.1%-99.99%). The accumulated data and samples are a considerable resource for further investigation of canine haemangiosarcoma and have a potential role in translational medicine.

在金毛猎犬终身研究中,血管肉瘤发生的描述性分析。
血管肉瘤是一种相对常见的犬类恶性肿瘤,也是金毛猎犬终身研究的主要结果之一。本研究收集了一组金毛猎犬的纵向数据和样本,目的是确定狗患癌症和其他重要疾病的营养、遗传、环境、生活方式和生殖风险因素。该分析描述了积累的数据和样本,可供研究人员使用,以实现研究的目标。截至2022年9月,参与该研究的233/3044只狗被诊断患有血管肉瘤(7.65%),每100只狗年的发病率为1.10例。内脏血管肉瘤最常见,影响211/3044只研究犬(6.9%)。128例内脏血管肉瘤诊断有脾脏肿瘤(60.7%),119例有心脏肿瘤(56.4%)。未诊断血管肉瘤的概率从大约4岁时的100%下降到12岁时的91.1% (95% CI为84.4%-98.3%),60.7% (95% CI为41.6%-88.6%),72.9% (95% CI为62.9%-84.6%)和70.0% (95% CI为53.4%-92.0%)。内脏血管肉瘤的1年生存率为1.42% (95% CI 0.37%-5.47%);皮肤血管肉瘤为84.6% (95% CI 67.1% ~ 99.99%)。积累的数据和样本为进一步研究犬血管肉瘤提供了可观的资源,并在转化医学中具有潜在的作用。
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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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