The rs9939609 Variant in FTO Increases the Risk of Hypercholesterolemia in Metabolically Healthy Subjects with Excess Weight.

IF 2 4区医学 Q3 GENETICS & HEREDITY

Lifestyle Genomics Pub Date : 2022-01-01 DOI:10.1159/000527097

Erika Sierra-Ruelas, Wendy Campos-Pérez, Nathaly Torres-Castillo, Pablo García-Solís, Barbara Vizmanos, Erika Martínez-López

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Abstract

Introduction: The fat mass and obesity-associated gene (FTO) is largely/primarily expressed in the hypothalamus. It plays a role in energy balance, regulation of food intake, and adipogenesis. According to metabolic phenotypes, studies have associated the FTO rs9939609 variant with body mass index (BMI), body fat mass, and dietary intake but not with serum lipids. This study aimed to analyze the association of the FTO rs9939609 variant with serum lipids in Mexican adults with different metabolic phenotypes.

Methods: We included 306 subjects aged 18-65 years, classified as normal weight or excess weight (EW) according to their BMI. EW included BMI from 25 to 39.9 kg/m2. Participants were classified into two metabolic phenotypes: metabolically healthy/metabolically unhealthy (MH/MUH). We use the homeostatic model assessment of insulin resistance and NCEP-ATP III cutoffs for glucose, triglycerides, high-density lipoprotein, and blood pressure. Subjects with ≥2 altered parameters were classified as MUH. The variant was determined by allelic discrimination with TaqMan® probes.

Results: In subjects with the A allele, significantly higher total cholesterol and low-density-lipoprotein cholesterol were found (p < 0.05). Furthermore, subjects with EW-MH and the AA or AT genotype had a significantly higher odds ratio for hypercholesterolemia (odds ratio 4.48, 95% confidence interval: 1.48-13.59, p = 0.008).

Conclusion: The FTO rs9939609 variant may influence serum lipid concentrations, increasing the risk of hypercholesterolemia.

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FTO中的rs9939609变异增加了超重代谢健康受试者高胆固醇血症的风险

脂肪量和肥胖相关基因(FTO)主要在下丘脑表达。它在能量平衡、调节食物摄入和脂肪形成中起作用。根据代谢表型，研究发现FTO rs9939609变异与体重指数(BMI)、体脂量和饮食摄入有关，但与血脂无关。本研究旨在分析具有不同代谢表型的墨西哥成年人FTO rs9939609变异与血脂的关系。方法:306例年龄在18-65岁之间，根据体重指数分为正常体重和超重体重(EW)。EW包括BMI从25到39.9 kg/m2。参与者被分为两种代谢表型:代谢健康/代谢不健康(MH/MUH)。我们使用稳态模型评估胰岛素抵抗和NCEP-ATP III切断葡萄糖、甘油三酯、高密度脂蛋白和血压。参数改变≥2项的受试者被归类为MUH。用TaqMan®探针进行等位基因鉴定。结果:携带A等位基因的受试者总胆固醇和低密度脂蛋白胆固醇显著升高(p < 0.05)。此外，EW-MH和AA或AT基因型的受试者发生高胆固醇血症的比值比显著更高(比值比4.48,95%可信区间:1.48-13.59,p = 0.008)。结论:FTO rs9939609变异可能影响血脂浓度，增加高胆固醇血症的发生风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lifestyle Genomics Agricultural and Biological Sciences-Food Science

CiteScore

4.00

自引率

7.70%

发文量

审稿时长

28 weeks

期刊介绍： Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.