Immune Cell Activation in Obesity and Cardiovascular Disease.

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Current Hypertension Reports Pub Date : 2022-12-01 Epub Date: 2022-09-22 DOI:10.1007/s11906-022-01222-4
Jamie N Garcia, Celestine N Wanjalla, Mona Mashayekhi, Alyssa H Hasty
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引用次数: 0

Abstract

Purpose of review: In this review, we focus on immune cell activation in obesity and cardiovascular disease, highlighting specific immune cell microenvironments present in individuals with atherosclerosis, non-ischemic heart disease, hypertension, and infectious diseases.

Recent findings: Obesity and cardiovascular disease are intimately linked and often characterized by inflammation and a cluster of metabolic complications. Compelling evidence from single-cell analysis suggests that obese adipose tissue is inflammatory and infiltrated by almost all immune cell populations. How this inflammatory tissue state contributes to more systemic conditions such as cardiovascular and infectious disease is less well understood. However, current research suggests that changes in the adipose tissue immune environment impact an individual's ability to combat illnesses such as influenza and SARS-CoV2. Obesity is becoming increasingly prevalent globally and is often associated with type 2 diabetes and heart disease. An increased inflammatory state is a major contributor to this association. Widespread chronic inflammation in these disease states is accompanied by an increase in both innate and adaptive immune cell activation. Acutely, these immune cell changes are beneficial as they sustain homeostasis as inflammation increases. However, persistent inflammation subsequently damages tissues and organs throughout the body. Future studies aimed at understanding the unique immune cell populations in each tissue compartment impacted by obesity may hold potential for therapeutic applications.

肥胖症和心血管疾病中的免疫细胞活化。
综述的目的:在这篇综述中,我们重点关注肥胖和心血管疾病中的免疫细胞活化,强调动脉粥样硬化、非缺血性心脏病、高血压和传染性疾病患者体内存在的特定免疫细胞微环境:肥胖与心血管疾病密切相关,通常以炎症和一系列代谢并发症为特征。来自单细胞分析的令人信服的证据表明,肥胖的脂肪组织具有炎症性,并被几乎所有的免疫细胞群浸润。这种炎症组织状态如何导致心血管疾病和传染病等全身性疾病,目前还不太清楚。不过,目前的研究表明,脂肪组织免疫环境的变化会影响个人抵抗流感和 SARS-CoV2 等疾病的能力。肥胖症在全球范围内越来越普遍,通常与 2 型糖尿病和心脏病有关。炎症状态的加剧是造成这种关联的主要原因。在这些疾病中,广泛的慢性炎症伴随着先天性和适应性免疫细胞激活的增加。急性期,这些免疫细胞的变化是有益的,因为它们能在炎症加剧时维持体内平衡。然而,持续的炎症随后会损害全身的组织和器官。未来的研究旨在了解受肥胖影响的每个组织区块中独特的免疫细胞群,这可能具有潜在的治疗应用价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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