Regulation of Mitochondrial Ca2+ Uptake.

IF 15.7 1区 医学 Q1 PHYSIOLOGY
Elizabeth Murphy, Charles Steenbergen
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引用次数: 17

Abstract

Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Ca2+ is a key modulator of both ATP production and cell death. Although mitochondrial Ca2+ uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Ca2+ uptake and efflux have been identified. The identification of the mitochondrial Ca2+ uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Ca2+ is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.

线粒体Ca2+摄取的调控。
线粒体负责ATP的产生,但也被称为细胞死亡的调节剂,线粒体基质Ca2+是ATP产生和细胞死亡的关键调节剂。虽然线粒体Ca2+摄取和外排已经研究了50多年,但直到过去十年,才确定了负责线粒体Ca2+摄取和外排的蛋白质。线粒体Ca2+单转运体(MCU)的鉴定导致了MCU调节因子研究的爆炸式增长。这些调节因子的水平以组织和疾病特异性的方式变化,为线粒体Ca2+如何调节提供了新的见解。这篇综述的重点是负责线粒体运输的蛋白质,以及我们从小鼠研究中了解到的这些蛋白质的遗传改变。
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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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