{"title":"Regulation of Mitochondrial Ca<sup>2+</sup> Uptake.","authors":"Elizabeth Murphy, Charles Steenbergen","doi":"10.1146/annurev-physiol-031920-092419","DOIUrl":null,"url":null,"abstract":"<p><p>Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Ca<sup>2+</sup> is a key modulator of both ATP production and cell death. Although mitochondrial Ca<sup>2+</sup> uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Ca<sup>2+</sup> uptake and efflux have been identified. The identification of the mitochondrial Ca<sup>2+</sup> uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Ca<sup>2+</sup> is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"83 ","pages":"107-126"},"PeriodicalIF":15.7000,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-031920-092419","citationCount":"17","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-physiol-031920-092419","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 17
Abstract
Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Ca2+ is a key modulator of both ATP production and cell death. Although mitochondrial Ca2+ uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Ca2+ uptake and efflux have been identified. The identification of the mitochondrial Ca2+ uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Ca2+ is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.
期刊介绍:
Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.