[Molecular basis of biological activity of polysaccharides in COVID-19 associated conditions].

Q3 Biochemistry, Genetics and Molecular Biology

Biomeditsinskaya khimiya Pub Date : 2022-12-01 DOI:10.18097/PBMC20226806403

E A Generalov, E Yu Simonenko, N G Kulchenko, L V Yakovenko

引用次数: 1

Abstract

The review considers the main molecular biological features of the COVID-19 causative agent, the SARS-CoV-2 virus: life cycle, viral cell penetration strategies, interactions of viral proteins with human proteins, cytopathic effects. We also analyze pathological conditions that occur both during the course of the COVID-19 disease and after virus elimination. A brief review of the biological activities of polysaccharides isolated from various sources is given, and possible molecular biological mechanisms of these activities are considered. Data analysis shows that polysaccharides are a class of biological molecules with wide potential for use in the treatment of both acute conditions in COVID-19 and post-COVID syndrome.

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[多糖在COVID-19相关条件下生物活性的分子基础]。

本文综述了COVID-19病原体SARS-CoV-2病毒的主要分子生物学特征:生命周期、病毒细胞渗透策略、病毒蛋白与人蛋白的相互作用、细胞病变效应。我们还分析了在COVID-19疾病过程中和病毒消除后发生的病理情况。本文综述了从不同来源分离的多糖的生物活性，并对其可能的分子生物学机制进行了探讨。数据分析表明，多糖是一类具有广泛潜力的生物分子，可用于治疗COVID-19急性病症和COVID-19后综合征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).