[Extracellular vesicles for diagnosis and therapy of gliomas: problems and opportunities].

Q3 Biochemistry, Genetics and Molecular Biology
A A Filin, A A Chernysheva, G V Pavlova, V B Loshhenov, O I Gurina
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引用次数: 0

Abstract

Glioblastoma is a primary brain tumor and one of the most aggressive malignant neoplasms. The prognosis remains poor with a short survival period after diagnosis even in the case of timely detection and early treatment with the use of advanced chemotherapy, radiation therapy and surgical treatment. In this regard, the research of the main pathogenetic links in the glioblastoma development continues. The current focus is on studying the molecular characteristics of tumours, including the analysis of extracellular vesicles, which play an essential role in intercellular communication processes. In this review, in order to provide up-to-date information on the role of extracellular vesicles in the diagnosis and therapy of gliomas, the analysis of the achieved results of Russian and foreign research related to this area has been carried out. The main goal of this review is to describe the features of extracellular vesicles as the containers and glioma marker transporters, as well as nucleic acids used in diagnosis and therapy.

细胞外囊泡用于胶质瘤的诊断和治疗:问题和机遇。
胶质母细胞瘤是一种原发性脑肿瘤,是最具侵袭性的恶性肿瘤之一。即使在及时发现和早期治疗的情况下,采用先进的化疗、放疗和手术治疗,诊断后预后仍较差,生存期短。在这方面,对胶质母细胞瘤发展的主要发病环节的研究仍在继续。目前的重点是研究肿瘤的分子特征,包括分析在细胞间通讯过程中起重要作用的细胞外囊泡。为了提供细胞外囊泡在胶质瘤诊断和治疗中的作用的最新信息,本文对国内外在这一领域的研究成果进行了分析。本文综述了细胞外囊泡作为胶质瘤的载体和标志物转运体的特点,以及在胶质瘤诊断和治疗中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomeditsinskaya khimiya
Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍: The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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