Cadmium exposure is associated with chronic kidney disease in a superfund site lead smelter community in Dallas, Texas.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2023-02-01 DOI:10.1080/03014460.2023.2236017

Bert B Little, Giang T Vu, Brad Walsh

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引用次数: 0

Abstract

Background: The study was conducted in a Dallas lead smelter community following an Environmental Protection Agency (EPA) Superfund Cleanup project. Lead smelters operated in the Dallas community since the mid-1930s.Aim: To test the hypothesis that cadmium (Cd) exposure is associated with chronic kidney disease (CKD) ≥ stage 3.Subjects and methods: Subjects were African American residents aged ≥19 to ≤ 89 years (n=835). CKD ≥ stage 3 was predicted by blood Cd concentration with covariates.Results: In logistic regression analysis, CKD ≥ stage 3 was predicted by age ≥ 50 years (OR = 4.41, p < 0.0001), Cd level (OR = 1.89, p < .05), hypertension (OR = 3.15, p < 0.03), decades living in the community (OR = 1.34, p < 0.003) and T2DM (OR = 2.51, p < 0.01). Meta-analysis of 11 studies of Cd and CKD ≥ stage 3 yielded an ORRANDOM of 1.40 (p < 0.0001). Chronic environmental Cd exposure is associated with CKD ≥ stage 3 in a Dallas lead smelter community controlling covariates.Conclusion: Public health implications include screening for heavy metals including Cd, cleanup efforts to remove Cd from the environment and treating CKD with newer renal-sparing medications (e.g., SGLT-2 inhibitors, GLP-1s).

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在德克萨斯州达拉斯市的一个铅冶炼厂社区，镉暴露与慢性肾病有关。

背景:这项研究是在环境保护署(EPA)超级基金清理项目之后在达拉斯铅冶炼厂社区进行的。自20世纪30年代中期以来，达拉斯社区就开始经营铅冶炼厂。目的:验证镉(Cd)暴露与慢性肾病(CKD)≥3期相关的假设。研究对象和方法:研究对象为年龄≥19 ~≤89岁的非裔美国居民(n=835)。血Cd浓度与协变量预测CKD≥3期。结果:在logistic回归分析中，年龄≥50岁(OR = 4.41, p < 0.0001)、Cd水平(OR = 1.89, p < 0.05)、高血压(OR = 3.15, p < 0.03)、社区生活年限(OR = 1.34, p < 0.003)和T2DM (OR = 2.51, p < 0.01)预测CKD≥3期。对11项Cd和CKD≥3期研究的荟萃分析显示，ORRANDOM为1.40 (p < 0.0001)。在达拉斯铅冶炼厂社区控制协变量中，慢性环境镉暴露与CKD≥3期相关。结论:公共卫生影响包括重金属(包括Cd)的筛查，清除环境中Cd的努力，以及使用更新的肾脏保护药物(例如SGLT-2抑制剂，glp -1)治疗CKD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.