Systemic Inflammation Response Index and Systemic Immune Inflammation Index Are Associated with Clinical Outcomes in Patients with Acute Pancreatitis?

IF 2.1 4区 医学 Q2 SURGERY
Murat Biyik, Zeynep Biyik, Mehmet Asil, Muharrem Keskin
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引用次数: 9

Abstract

Objectives: The inflammatory response is critically important in acute pancreatitis (AP). Systemic immune-inflammation (SII) index and systemic inflammation response index (SIRI), which are novel inflammatory markers, have been linked to determining outcomes in various diseases. The goal of the current study was to examine the relation of the SII index and SIRI with disease severity and acute kidney injury (AKI) in subjects with AP.

Methods: A total of 332 subjects with AP were analyzed retrospectively. SII index was calculated using the formula; platelet (P)×neutrophil (N)/lymphocyte (L), while SIRI was calculated as N × monocyte (M)/L count. Multivariate regression (MR) was done to determine the independent risk factors for AKI and severe AP (SAP).

Results: Statistical analyses showed that both median SII index and median SIRI increased gradually with higher AP severity (p < 0.001). Both SII index and SIRI were higher in subjects with AKI compared to controls (p < 0.001). Using MR analysis, the SII index was found to independently predict both SAP (OR = 1.004, 95% CI: 1.001-1.008, p = 0.018) and AKI (OR = 1.005, 95% CI: 1.003-1.008, p < 0.001). ROC analysis showed that the SII index could accurately differentiate SAP (AUC = 0.809, p < 0.001) and AKI (AUC = 0.820, p = 0.001) in patients with acute pancreatitis. ROC analysis also showed that SIRI could also accurately differentiate SAP (0.782, p < 0.001) and AKI (AUC = 0.776, p = 0.001).

Conclusions: SIRI and the SII indexes can be used as potential biomarkers in predicting both disease severity and AKI development in subjects with AP.

全身性炎症反应指数和全身性免疫炎症指数与急性胰腺炎患者的临床结局有关?
目的:炎症反应在急性胰腺炎(AP)中至关重要。系统性免疫炎症(SII)指数和系统性炎症反应指数(SIRI)是一种新的炎症标志物,与多种疾病的预后有关。本研究旨在探讨AP患者SII指数和SIRI与疾病严重程度和急性肾损伤(AKI)的关系。方法:对332例AP患者进行回顾性分析。SII指数采用公式计算;血小板(P)×neutrophil (N)/淋巴细胞(L), SIRI计算为N ×单核细胞(M)/L计数。采用多变量回归(MR)确定AKI和严重AP (SAP)的独立危险因素。结果:统计分析显示,急性胰腺炎患者SII指数中位值和SIRI中位值随AP严重程度(p p = 0.018)和AKI (OR = 1.005, 95% CI: 1.003-1.008, p p p = 0.001)的升高而逐渐升高。ROC分析也显示SIRI也能准确区分SAP (0.782, p p = 0.001)。结论:SIRI和SII指标可作为预测AP患者疾病严重程度和AKI发展的潜在生物标志物。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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