Stomatin-like protein-2 contributes the migration and invasion of breast cancer cells via regulating ERK/FOXO3a signaling pathway.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-07-01 DOI:10.4103/cjop.CJOP-D-22-00117

Shengming Wu, Lingang Zhao, Qian Li

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引用次数: 0

Abstract

Breast cancer (BC) is the most common tumor in women, and its incidence is increasing, ranking first among female malignant tumors. It is urgently needed to find new and reliable biomarkers of BC and to understand the cellular changes that cause metastasis. Stomatin-like protein-2 (SLP-2) is a member of the stomatin protein superfamily. Studies have shown that SLP-2 was highly expressed in some tumors and played an important role in tumor genesis and development. SLP-2 regulated the extracellular signal-regulated kinase (ERK) pathway, and activation of ERK phosphorylated FOXO3a, which was involved in BC progression. However, its possible role in the progression of BC remains unclear. In this study, we found the high expression of SLP-2 in BC tissues and cells. SLP-2 promoted the viability of BC cells. In addition, we found that SLP-2 stimulated the motility of BC cells in vitro. Mechanically, our results revealed that SLP-2 could mediate FOXO3a expression and ERK signaling pathway, thereby contributing to the viability and motility of BC cells. Therefore, SLP-2 has the potential to serve as a promising target for BC treatment.

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气孔样蛋白-2通过调节ERK/FOXO3a信号通路参与乳腺癌症细胞的迁移和侵袭。

癌症是女性最常见的肿瘤，其发病率不断上升，居女性恶性肿瘤之首。迫切需要找到新的可靠的BC生物标志物，并了解导致转移的细胞变化。气孔蛋白样蛋白-2（SLP-2）是气孔蛋白超家族的一员。研究表明，SLP-2在某些肿瘤中高表达，在肿瘤的发生和发展中发挥着重要作用。SLP-2调节细胞外信号调节激酶（ERK）通路，并激活ERK磷酸化的FOXO3a，后者参与BC的进展。然而，它在不列颠哥伦比亚省的发展中可能发挥的作用尚不清楚。在本研究中，我们发现SLP-2在BC组织和细胞中高表达。SLP-2可促进BC细胞的活力。此外，我们发现SLP-2在体外刺激BC细胞的运动。从机制上讲，我们的研究结果表明，SLP-2可以介导FOXO3a的表达和ERK信号通路，从而有助于BC细胞的活力和运动性。因此，SLP-2有潜力成为BC治疗的一个有前景的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.