Sensitization patterns to Poaceae pollen indicates a hierarchy in allergens and a lead of tropical grasses

IF 4.6 2区医学 Q2 ALLERGY

Clinical and Translational Allergy Pub Date : 2023-08-07 DOI:10.1002/clt2.12287

Victoria Rodinkova, Serhii Yuriev, Vitalii Mokin, Olena Sharikadze, Yevhenii Kryzhanovskyi, Lilia Kremenska, Olha Kaminska, Andrii Kurchenko

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Abstract

Background

The allergenicity of pollen of Poaceae family members is a well-known and confirmed fact. Using the data of component-resolved molecular diagnostics of allergy, we set a goal to establish the population and individual characteristics of sensitization to grass pollen and assess the patterns of its development.

Methods

Multiplex allergy Alex² test results of 20,033 patients were used. In addition to descriptive statistics to uncover traits of the sensitized population, statistical inference was utilized to establish the conditional probability of sensitisation, the nature of links between allergens, and the most frequent combinations of allergens in individual patient profiles.

Results

Sensitivity to grass pollen comprised 30.79% of the studied sample. Children accounted for 62.21%, adults—37.79%. Sensitisation to Phl p 1, Lol p 1, and Cyn d 1 was the most frequent in all age groups. Among them, Phl p 1 and Lol p 1 were the major ones. Phl p 2, Phl p 5.0101, and Phl p 6 were also responsible for primary sensitization; Phl p 5.0101 promoted the highest sIgE levels. A combination “Lol p 1—Phl p 1”, where Lol p 1 might play a leading role, was most frequent in individual profiles. Monosensitization to Phl p 2 was the second most frequent and Bayesian Network suggested its independent development. Monosensitization to Cyn d 1, especially among children, may indicate the impact of climate change, promoting the spread of the subtropical grasses to the temperate region.

Conclusions

Descriptive statistics and known clinical data coincide well with statistical inference results and can provide for new clinical insights.

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对禾本科花粉的致敏模式表明过敏原的等级和热带草的领导

背景禾本科植物花粉的致敏性是众所周知的事实。利用成分分解的过敏分子诊断数据，我们的目标是建立对草花粉敏感的群体和个体特征，并评估其发展模式。方法采用20033例患者多重过敏Alex2试验结果。除了描述性统计来揭示致敏人群的特征，统计推断被用来建立致敏的条件概率，过敏原之间联系的性质，以及个体患者档案中最常见的过敏原组合。结果对草花粉的敏感性为30.79%。儿童占62.21%，成人占37.79%。Phl p1、Lol p1和cynd1的致敏在所有年龄组中最为常见。其中以Phl p1和Lol p1为主。Phl p2、Phl p5.0101和Phl p6也负责初级致敏;php5.0101促进最高sIgE水平。一个组合“Lol p1 - p1”，其中Lol p1可能起主导作用，在个人档案中最常见。对Phl p2的单致敏是第二常见的，贝叶斯网络提示其独立发展。对cyd1的单致敏，尤其是儿童，可能表明气候变化的影响，促进了亚热带禾草向温带地区的传播。结论描述性统计与已知临床资料吻合较好，可为临床提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Allergy Immunology and Microbiology-Immunology

CiteScore

7.50

自引率

4.50%

发文量

117

审稿时长

12 weeks

期刊介绍： Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.

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