Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease.

IF 2.3 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephron Pub Date : 2024-01-01 Epub Date: 2023-05-15 DOI:10.1159/000530918

Ibrahim Sandokji, Yunwen Xu, Michelle Denburg, Susan Furth, Alison G Abraham, Jason H Greenberg

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引用次数: 0

Abstract

Background: Due to the complexity of chronic kidney disease (CKD) pathophysiology, biomarkers representing different mechanistic pathways have been targeted for the study and development of novel biomarkers. The discovery of clinically useful CKD biomarkers would allow for the identification of those children at the highest risk of kidney function decline for timely interventions and enrollment in clinical trials.

Summary: Glomerular filtration rate and proteinuria are traditional biomarkers to classify and prognosticate CKD progression in clinical practice but have several limitations. Over the recent decades, novel biomarkers have been identified from blood or urine with metabolomic screening studies, proteomic screening studies, and an improved knowledge of CKD pathophysiology. This review highlights promising biomarkers associated with the progression of CKD that could potentially serve as future prognostic markers in children with CKD.

Key messages: Further studies are needed in children with CKD to validate putative biomarkers, particularly candidate proteins and metabolites, for improving clinical management.

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慢性肾脏病儿童进展风险的现有和新型生物标志物。

背景：由于慢性肾脏病（CKD）病理生理学的复杂性，代表不同机制途径的生物标志物已成为研究和开发新型生物标志物的目标。摘要：肾小球滤过率和蛋白尿是临床实践中对慢性肾脏病进展进行分类和预后的传统生物标志物，但存在一些局限性。近几十年来，随着代谢组学筛选研究、蛋白质组学筛选研究以及对 CKD 病理生理学认识的提高，人们从血液或尿液中发现了新的生物标志物。本综述重点介绍了与 CKD 进展相关的有希望的生物标志物，这些标志物有可能成为 CKD 儿童的预后标志物：关键信息：需要对 CKD 儿童进行进一步研究，以验证推测的生物标志物，尤其是候选蛋白质和代谢物，从而改善临床管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephron UROLOGY & NEPHROLOGY-

CiteScore

5.00

自引率

0.00%

发文量

期刊介绍： ''Nephron'' comprises three sections, which are each under the editorship of internationally recognized leaders and served by specialized Associate Editors. Apart from high-quality original research, ''Nephron'' publishes invited reviews/minireviews on up-to-date topics. Papers undergo an innovative and transparent peer review process encompassing a Presentation Report which assesses and summarizes the presentation of the paper in an unbiased and standardized way.