An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2023-08-12 DOI:10.1016/j.npep.2023.102369

Sukanya Singh , Mitali Mahajan , Dhawal Kumar, Kunika Singh, Mehvish Chowdhary, Amit

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引用次数: 1

Abstract

Alzheimer's disease (AD) has remained elusive in revealing its pathophysiology and mechanism of development. In this review paper, we attempt to highlight several theories that abound about the exact pathway of AD development. The number of cases worldwide has prompted a constant flow of research to detect high-risk patients, slow the progression of the disease and discover improved methods of treatment that may prove effective. We shall focus on the two main classes of drugs that are currently in use; and emerging ones with novel mechanisms that are under development. As of late there has also been increased attention towards factors that were previously thought to be unrelated to AD, such as the gut microbiome, lifestyle habits, and diet. Studies have now shown that all these factors make an impact on AD progression, thus bringing to our attention more areas that could hold the key to combating this disease. This paper covers all the aforementioned factors concisely. We also briefly explore the relationship between mental health and AD, both before and after the diagnosis of the disease.

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一项关于阿尔茨海默病最新进展的包容性研究:全面回顾

阿尔茨海默病（AD）在揭示其病理生理学和发展机制方面仍然难以捉摸。在这篇综述文章中，我们试图强调关于AD发展确切途径的几种理论。全球范围内的病例数量促使不断进行研究，以发现高风险患者，减缓疾病进展，并发现可能被证明有效的改进治疗方法。我们将重点关注目前正在使用的两类主要药物；以及正在开发的具有新机制的新兴机制。最近，人们也越来越关注以前被认为与AD无关的因素，如肠道微生物组、生活习惯和饮食。现在的研究表明，所有这些因素都会对AD的进展产生影响，从而使我们注意到更多可能是对抗这种疾病关键的领域。本文简要介绍了上述所有因素。我们还简要探讨了在疾病诊断前后心理健康与AD之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.