The restoration ability of a short nap after sleep deprivation on the brain cognitive function: A dynamic functional connectivity analysis

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2023-08-22 DOI:10.1111/cns.14413

Ziliang Xu, Yingjuan Chang, Fan Guo, Chen Wang, Na Chai, Minwen Zheng, Peng Fang, Yuanqiang Zhu

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Abstract

Aims

The brain function impairment induced by sleep deprivation (SD) is temporary and can be fully reversed with sufficient sleep. However, in many cases, long-duration recovery sleep is not feasible. Thus, this study aimed to investigate whether a short nap after SD is sufficient to restore brain function.

Methods

The data of 38 subjects, including resting state functional magnetic resonance imaging data collected at three timepoints (before SD, after 30 h of SD, and after a short nap following SD) and psychomotor vigilance task (PVT) data, were collected. Dynamic functional connectivity (DFC) analysis was used to evaluate changes in brain states among three timepoints, and four DFC states were distinguished across the three timepoints.

Results

Before SD, state 2 (a resting-like FC matrix) was dominant (48.26%). However, after 30 h SD, the proportion of state 2 dramatically decreased, and state 3 (still resting-like, but FCs were weakened) became dominant (40.92%). The increased proportion of state 3 positively correlated with a larger PVT “lapse” time. After a nap, the proportions of states 2 and 3 significantly increased and decreased, respectively, and the change in proportion of state 2 negatively correlated with the change in PVT “lapse” time.

Conclusions

Taken together, the results indicated that, after a nap, the cognitive function impairment caused by SD may be reversed to some extent. Additionally, DFC differed among timepoints, which was also associated with the extent of cognitive function impairment after SD (state 3) and the extent of recovery therefrom after a nap (state 2).

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睡眠不足后小睡片刻对大脑认知功能的恢复能力：动态功能连接分析

目的睡眠不足（SD）引起的大脑功能损伤是暂时的，充足的睡眠可以完全逆转。然而，在许多情况下，长时间的恢复性睡眠并不可行。因此，本研究旨在探讨睡眠不足后小睡片刻是否足以恢复大脑功能。方法收集了 38 名受试者的数据，包括在三个时间点（自毁前、自毁 30 小时后和自毁后小睡片刻）采集的静息状态功能磁共振成像数据和精神运动警觉任务（PVT）数据。采用动态功能连接（DFC）分析评估三个时间点之间大脑状态的变化，并在三个时间点之间区分出四种DFC状态。结果在标化前，状态 2（静息样 FC 矩阵）占主导地位（48.26%）。然而，在标化 30 小时后，状态 2 的比例急剧下降，状态 3（仍类似静息，但 FC 已减弱）成为主导（40.92%）。状态 3 比例的增加与 PVT "失效 "时间的延长呈正相关。午睡后，状态 2 和状态 3 的比例分别显著增加和减少，状态 2 比例的变化与 PVT "失效 "时间的变化呈负相关。结论综上所述，研究结果表明，午睡后，SD 所导致的认知功能损害可能会在一定程度上得到逆转。此外，DFC 在不同时间点的变化也与 SD 后认知功能受损的程度（状态 3）和午睡后认知功能恢复的程度（状态 2）有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.