Efficacy of Individualized Homeopathic Medicines in Treatment of Acne Vulgaris: A Double-Blind, Randomized, Placebo-Controlled Trial.

IF 1.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Homeopathy Pub Date : 2022-11-01 DOI:10.1055/s-0041-1739397

Shruti Rai, Gobind Narayan Gupta, Subhas Singh, James Michael, Pankhuri Misra, Bharti Gupta, Suman Singh, Akshaya Prakash, Maneela Tomar, Satarupa Sadhukhan, Munmun Koley, Subhranil Saha

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引用次数: 3

Abstract

Background: Acne is estimated to affect 9.4% of the global population, making it the 8^th most prevalent disease worldwide. Acne vulgaris (AV) is among the diseases that directly affect quality of life. This trial evaluated the efficacy of individualized homeopathic medicines (IHM) against placebo in AV.

Methods: In this double-blind, randomized, placebo-controlled trial conducted at the National Institute of Homoeopathy, India, 126 patients suffering from AV were randomized in a 1:1 ratio to receive either IHM (verum) in centesimal potencies or identical-looking placebo (control). The primary outcome measure was the Global Acne Grading System score; secondary outcomes were the Cardiff Acne Disability Index and Dermatology Life Quality Index questionnaires - all measured at baseline and 3 months after the intervention. Group differences and effect sizes (Cohen's d) were calculated on the intention-to-treat sample.

Results: Overall, improvements were greater in the IHM group than placebo, with small to medium effect sizes after 3 months of intervention; however, the inter-group differences were statistically non-significant. Sulphur (17.5%), Natrum muriaticum (15.1%), Calcarea phosphorica (14.3%), Pulsatilla nigricans (10.3%), and Antimonium crudum (7.1%) were the most frequently prescribed medicines; Pulsatilla nigricans, Tuberculinum bovinum and Natrum muriaticum were the most effective of those used. No harms, unintended effects, homeopathic aggravations or any serious adverse events were reported from either group.

Conclusion: There was non-significant direction of effect favoring homeopathy against placebo in the treatment of AV.

Trial registration: CTRI/2018/11/016248; UTN: U1111-1221-8164.

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个体化顺势疗法药物治疗寻常痤疮的疗效:一项双盲、随机、安慰剂对照试验。

背景:据估计，痤疮影响了全球9.4%的人口，使其成为全球第八大流行疾病。寻常痤疮(AV)是直接影响生活质量的疾病之一。方法:在印度国家顺势疗法研究所进行的这项双盲、随机、安慰剂对照试验中，126名AV患者以1:1的比例随机接受百分效的IHM (verum)或相同外观的安慰剂(control)。主要结局指标为全球痤疮分级系统评分;次要结果是卡迪夫痤疮残疾指数和皮肤病生活质量指数问卷调查-均在基线和干预后3个月测量。在意向治疗样本上计算组间差异和效应量(Cohen’s d)。结果:总体而言，IHM组的改善大于安慰剂组，干预3个月后效果较小;然而，组间差异无统计学意义。硫(17.5%)、自然碱(15.1%)、磷酸钙(14.3%)、白头翁(10.3%)和粗锑(7.1%)是最常见的处方药;白头翁、牛结核菌和自然碱是最有效的。两组均无伤害、意外效应、顺势疗法加重或任何严重不良事件的报告。结论:顺势疗法治疗av优于安慰剂的效果方向不显著。试验注册号:CTRI/2018/11/016248;UTN: u1111 - 1221 - 8164。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Homeopathy 医学-全科医学与补充医学

CiteScore

3.40

自引率

70.60%

发文量

审稿时长

20.1 weeks

期刊介绍： Homeopathy is an international peer-reviewed journal aimed at improving the fundamental understanding and clinical practice of homeopathy by publishing relevant high-quality original research articles, reviews, and case reports. It also promotes commentary and debate on matters of topical interest in homeopathy.