Educational Attainment Polygenic Scores: Examining Evidence for Gene-Environment Interplay with Adolescent Alcohol, Tobacco and Cannabis Use.

IF 1 4区医学 Q4 GENETICS & HEREDITY

Twin Research and Human Genetics Pub Date : 2022-10-01 Epub Date: 2022-10-03 DOI:10.1017/thg.2022.33

Christal N Davis, Ian R Gizer, Lucía Colodro-Conde, Dixie J Statham, Nicholas G Martin, Wendy S Slutske

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引用次数: 0

Abstract

Genes associated with educational attainment may be related to or interact with adolescent alcohol, tobacco and cannabis use. Potential gene-environment interplay between educational attainment polygenic scores (EA-PGS) and adolescent alcohol, tobacco, and cannabis use was evaluated with a series of regression models fitted to data from a sample of 1871 adult Australian twins. All models controlled for age, age², cohort, sex and genetic ancestry as fixed effects, and a genetic relatedness matrix was included as a random effect. Although there was no evidence that adolescent alcohol, tobacco or cannabis use interacted with EA-PGS to influence educational attainment, there was a significant, positive gene-environment correlation with adolescent alcohol use at all PGS thresholds (ps <.02). Higher EA-PGS were associated with an increased likelihood of using alcohol as an adolescent (ΔR² ranged from 0.5% to 1.1%). The positive gene-environment correlation suggests a complex relationship between educational attainment and alcohol use that is due to common genetic factors.

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教育成就多基因分数：研究青少年使用酒精、烟草和大麻的基因与环境相互作用的证据。

与受教育程度相关的基因可能与青少年酗酒、吸烟和吸食大麻有关，或与之相互影响。通过一系列回归模型，评估了教育程度多基因评分（EA-PGS）与青少年酗酒、吸烟和吸食大麻之间潜在的基因-环境相互作用，这些模型适用于 1871 个澳大利亚成年双胞胎样本数据。所有模型都将年龄、年龄2、队列、性别和遗传血统作为固定效应进行了控制，并将遗传亲缘关系矩阵作为随机效应纳入其中。虽然没有证据表明青少年酒精、烟草或大麻的使用与 EA-PGS 相互影响教育程度，但在所有 PGS 临界值下，青少年酒精使用与基因-环境存在显著的正相关（ps R2 在 0.5% 到 1.1% 之间）。基因与环境的正相关性表明，受教育程度与饮酒之间的复杂关系是由共同的遗传因素造成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Twin Research and Human Genetics 医学-妇产科学

CiteScore

1.50

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Twin Research and Human Genetics is the official journal of the International Society for Twin Studies. Twin Research and Human Genetics covers all areas of human genetics with an emphasis on twin studies, genetic epidemiology, psychiatric and behavioral genetics, and research on multiple births in the fields of epidemiology, genetics, endocrinology, fetal pathology, obstetrics and pediatrics. Through Twin Research and Human Genetics the society aims to publish the latest research developments in twin studies throughout the world.