Longitudinal characterization of patients with progressive apraxia of speech without clearly predominant phonetic or prosodic speech features

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Rene L. Utianski , Gabriela Meade , Joseph R. Duffy , Heather M. Clark , Hugo Botha , Mary M. Machulda , Dennis W. Dickson , Jennifer L. Whitwell , Keith A. Josephs
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引用次数: 0

Abstract

Most recent studies of progressive apraxia of speech (PAOS) have focused on patients with phonetic or prosodic predominant PAOS to understand the implications of the presenting clinical phenotype. Patients without a clearly predominating speech quality, or mixed AOS, have been excluded. Given the implications for disease progression, it is important to understand these patients early in the disease course to inform appropriate education and prognostication. The aim of this study was to describe a cohort of ten patients with initially mixed PAOS and how their clinical course evolves. Four patients were rated prosodic predominant later on (mild AOS at first visit); five were later designated phonetic (four with more than mild AOS at first visit); one was judged mixed at all visits. The study suggests patients without a clear predominance of speech features should still be included in PAOS studies and thought of on the continuum of the disease spectrum.

进行性言语失用症患者的纵向特征,无明显的主要语音或韵律语音特征。
最近对进行性言语失用症(PAOS)的研究大多集中在以语音或韵律为主的PAOS患者身上,以了解其临床表型的含义。没有明显占主导地位的语音质量或混合AOS的患者被排除在外。考虑到对疾病进展的影响,重要的是在病程早期了解这些患者,为适当的教育和预测提供信息。本研究的目的是描述一个由10名最初混合PAOS患者组成的队列,以及他们的临床病程如何演变。四名患者后来被评为韵律为主(第一次就诊时轻度AOS);五个后来被指定为语音(四个在第一次就诊时AOS超过轻度);在所有访问中都有一个被认为是好坏参半。这项研究表明,没有明显优势言语特征的患者仍应被纳入PAOS研究,并被认为是疾病谱的连续体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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