A case study on the influence of hydrophilicity on the signal enhancement by dynamic nuclear polarization

IF 1.8 3区化学 Q4 CHEMISTRY, PHYSICAL

Solid state nuclear magnetic resonance Pub Date : 2022-12-01 DOI:10.1016/j.ssnmr.2022.101829

Sonja C. Döller , Torsten Gutmann , Markus Hoffmann , Gerd Buntkowsky

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引用次数: 1

Abstract

In this work, the behavior of four different commercially available polarizing agents is investigated employing the non-ionic model surfactant 1-octanol as analyte. A relative method for the comparison of the proportion of the direct and indirect polarization transfer pathways is established, allowing a direct comparison of the polarization efficacy for different radicals and different parts of the 1-octanol molecule despite differences in radical concentration or sample amount. With this approach, it could be demonstrated that the hydrophilicity is a key factor in the way polarization is transferred from the polarizing agent to the analyte. These findings are confirmed by the determination of buildup times T_b, illustrating that the choice of polarizing agent plays an essential role in ensuring an optimal polarization transfer and therefore the maximum amount of enhancement possible for DNP enhanced NMR measurements.

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亲水性对动态核极化信号增强影响的实例研究

在这项工作中，研究了四种不同的市售极化剂的行为，采用非离子模型表面活性剂1-辛醇作为分析物。建立了一种比较直接和间接极化转移途径比例的相对方法，可以直接比较不同自由基和1-辛醇分子不同部位的极化效率，而不管自由基浓度或样品量的不同。通过这种方法，可以证明亲水性是极化从极化剂转移到分析物的关键因素。这些发现通过累积时间Tb的测定得到了证实，说明极化剂的选择在确保最佳极化转移和DNP增强核磁共振测量的最大增强量方面起着至关重要的作用。

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来源期刊

Solid state nuclear magnetic resonance 物理-光谱学

CiteScore

5.30

自引率

9.40%

发文量

审稿时长

72 days

期刊介绍： The journal Solid State Nuclear Magnetic Resonance publishes original manuscripts of high scientific quality dealing with all experimental and theoretical aspects of solid state NMR. This includes advances in instrumentation, development of new experimental techniques and methodology, new theoretical insights, new data processing and simulation methods, and original applications of established or novel methods to scientific problems.