Production of carrier/antioxidant particles by Supercritical Assisted Atomization as an adjuvant treatment of the CoVID-19 pathology

IF 3.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids Pub Date : 2022-07-01 DOI:10.1016/j.supflu.2022.105604

Iolanda De Marco

{"title":"Production of carrier/antioxidant particles by Supercritical Assisted Atomization as an adjuvant treatment of the CoVID-19 pathology","authors":"Iolanda De Marco","doi":"10.1016/j.supflu.2022.105604","DOIUrl":null,"url":null,"abstract":"<div><p>The 2019 coronavirus outbreak caused a global health emergency. Some therapeutic strategies for this pathology focus on natural compounds, such as flavonoids, because of their antimicrobial and antiviral properties. However, the therapeutic efficacy of these active compounds is limited by their low bioavailability. In this paper, composite systems consisting of the flavonoid and a carrier were produced by Supercritical Assisted Atomization to increase these compounds’ dissolution rate. Luteolin, rutin, and naringenin were selected as model flavonoids, and hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone were chosen as the carriers. Hydroxypropyl-β-cyclodextrin was the most suitable carrier, in terms of recovery, morphology/size of the particles, and dissolution rate of the active compound. At the best operating conditions, the dissolution rate of the active principle is speeded for all the flavonoids: in particular, if compared to the virgin materials, it is 55.8 times faster for luteolin, 3.1 times faster for rutin and 3.4 times faster for naringenin.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"186 ","pages":"Article 105604"},"PeriodicalIF":3.4000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994258/pdf/","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Supercritical Fluids","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0896844622000894","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 4

Abstract

The 2019 coronavirus outbreak caused a global health emergency. Some therapeutic strategies for this pathology focus on natural compounds, such as flavonoids, because of their antimicrobial and antiviral properties. However, the therapeutic efficacy of these active compounds is limited by their low bioavailability. In this paper, composite systems consisting of the flavonoid and a carrier were produced by Supercritical Assisted Atomization to increase these compounds’ dissolution rate. Luteolin, rutin, and naringenin were selected as model flavonoids, and hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone were chosen as the carriers. Hydroxypropyl-β-cyclodextrin was the most suitable carrier, in terms of recovery, morphology/size of the particles, and dissolution rate of the active compound. At the best operating conditions, the dissolution rate of the active principle is speeded for all the flavonoids: in particular, if compared to the virgin materials, it is 55.8 times faster for luteolin, 3.1 times faster for rutin and 3.4 times faster for naringenin.

Abstract Image

查看原文本刊更多论文

超临界辅助雾化制备载体/抗氧化颗粒作为CoVID-19病理的辅助治疗

2019年冠状病毒爆发引发了全球卫生紧急情况。这种病理的一些治疗策略集中在天然化合物，如类黄酮，因为它们具有抗菌和抗病毒特性。然而，这些活性化合物的治疗效果受到其低生物利用度的限制。本文采用超临界辅助雾化法制备了黄酮类化合物与载体的复合体系，以提高其溶出率。以木犀草素、芦丁、柚皮素为模型黄酮类化合物，羟丙基-β-环糊精和聚乙烯吡咯烷酮为载体。以羟丙基-β-环糊精为载体，从回收率、颗粒形貌/大小、活性化合物的溶出率等方面考虑，均为最佳载体。在最佳操作条件下，所有黄酮类化合物的有效成分溶出速度均加快，其中木犀草素溶出速度加快55.8倍，芦丁溶出速度加快3.1倍，柚皮素溶出速度加快3.4倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Supercritical Fluids 工程技术-工程：化工

CiteScore

7.60

自引率

10.30%

发文量

236

审稿时长

56 days

期刊介绍： The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.