Therapeutic Approaches for the Treatment of Interstitial Lung Disease: An Exploratory Review on Molecular Mechanisms.

IF 3.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/1389557523666230816090112

Revati Amin, Ruchi Pandey, K Vaishali, Vishak Acharya, Mukesh Kumar Sinha, Nitesh Kumar

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引用次数: 0

Abstract

Background: Interstitial Lung Diseases (ILDs) are characterized by shortness of breath caused by alveolar wall inflammation and/or fibrosis.

Objective: Our review aims to study the depth of various variants of ILD, diagnostic procedures, pathophysiology, molecular dysfunction and regulation, subject and objective assessment techniques, pharmacological intervention, exercise training and various modes of delivery for rehabilitation.

Method: Articles are reviewed from PubMed and Scopus and search engines.

Results: ILD is a rapidly progressing disease with a high mortality rate. Each variant has its own set of causal agents and expression patterns. Patients often find it challenging to self-manage due to persistent symptoms and a rapid rate of worsening. The present review elaborated on the pathophysiology, risk factors, molecular mechanisms, diagnostics, and therapeutic approaches for ILD will guide future requirements in the quest for innovative and tailored ILD therapies at the molecular and cellular levels.

Conclusion: The review highlights the rationale for conventional and novel therapeutic approaches for better management of ILD.

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治疗间质性肺病的治疗方法：分子机制探索性综述》。

背景：肺间质疾病（ILDs）的特征是肺泡壁炎症和/或纤维化引起的呼吸急促：我们的综述旨在深入研究 ILD 的各种变异、诊断程序、病理生理学、分子功能障碍和调节、主客观评估技术、药物干预、运动训练和各种康复模式：方法：从PubMed、Scopus和搜索引擎中查阅相关文章：ILD是一种进展迅速、死亡率高的疾病。每种变异都有自己的致病因素和表达模式。由于症状持续存在且恶化速度快，患者往往发现自我管理具有挑战性。本综述详细阐述了 ILD 的病理生理学、风险因素、分子机制、诊断和治疗方法，将指导未来在分子和细胞层面寻求创新和定制 ILD 治疗方法的需求：本综述强调了为更好地管理 ILD 而采用传统和新型治疗方法的理由。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mini reviews in medicinal chemistry 医学-医药化学

CiteScore

7.80

自引率

0.00%

发文量

231

审稿时长

6 months

期刊介绍： The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.