Diagnostic performance of F-18 FDG PET or PET/CT for detection of recurrent gastric cancer: a systematic review and meta-analysis.

IF 1 Q3 MEDICINE, GENERAL & INTERNAL
Journal of Yeungnam medical science Pub Date : 2023-11-01 Epub Date: 2023-08-17 DOI:10.12701/jyms.2023.00220
Chang In Choi, Jae Kyun Park, Tae Yong Jeon, Dae-Hwan Kim
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引用次数: 0

Abstract

Background: This systematic review and meta-analysis investigated the diagnostic performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT) for the detection of disease recurrence after curative resection of gastric cancer.

Methods: The PubMed and Embase databases, from the earliest available date of indexing through November 30, 2019, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT to detect recurrent disease after gastric cancer surgery.

Results: Across 17 studies (1,732 patients), the pooled sensitivity for F-18 FDG PET or PET/CT was 0.82 (95% confidence interval [CI], 0.74-0.88) with heterogeneity of I2=76.5 (p<0.001), and the specificity was 0.86 (95% CI, 0.78-0.91) with heterogeneity of I2=94.2 (p<0.001). Likelihood ratio (LR) tests gave an overall positive LR of 6.0 (95% CI, 3.6-9.7) and negative LR of 0.2 (95% CI, 0.14-0.31). The pooled diagnostic odds ratio was 29 (95% CI, 13-63). The summary receiver operating characteristic curve indicates that the area under the curve was 0.91 (95% CI, 0.88-0.93).

Conclusion: The current meta-analysis showed good sensitivity and specificity of F-18 FDG PET or PET/CT for detecting recurrent disease after curative resection of gastric cancer despite heterogeneity in ethnicity, recurrence rate, histology, and interpretation method.

F-18 FDG PET或PET/CT对胃癌复发的诊断价值:一项系统综述和荟萃分析
背景:本系统综述和荟萃分析探讨了F-18氟脱氧葡萄糖(FDG)正电子发射断层扫描(PET)或PET/计算机断层扫描(PET/CT)对胃癌根治性切除术后疾病复发的诊断价值。方法:检索PubMed和Embase数据库,从最早可检索日期到2019年11月30日,检索评估F-18 FDG PET或PET/CT检测胃癌术后复发性疾病诊断性能的研究。结果:在17项研究(1732例患者)中,F-18 FDG PET或PET/CT的总敏感性为0.82(95%可信区间[CI], 0.74-0.88),异质性为I2=76.5(结论:本荟萃分析显示,尽管种族、复发率、组织学和解释方法存在异质性,但F-18 FDG PET或PET/CT检测胃癌根治性切除术后复发疾病的敏感性和特异性良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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