Diagnostic performance of F-18 FDG PET or PET/CT for detection of recurrent gastric cancer: a systematic review and meta-analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-01 Epub Date: 2023-08-17 DOI:10.12701/jyms.2023.00220

Chang In Choi, Jae Kyun Park, Tae Yong Jeon, Dae-Hwan Kim

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引用次数: 0

Abstract

Background: This systematic review and meta-analysis investigated the diagnostic performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT) for the detection of disease recurrence after curative resection of gastric cancer.

Methods: The PubMed and Embase databases, from the earliest available date of indexing through November 30, 2019, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT to detect recurrent disease after gastric cancer surgery.

Results: Across 17 studies (1,732 patients), the pooled sensitivity for F-18 FDG PET or PET/CT was 0.82 (95% confidence interval [CI], 0.74-0.88) with heterogeneity of I2=76.5 (p<0.001), and the specificity was 0.86 (95% CI, 0.78-0.91) with heterogeneity of I2=94.2 (p<0.001). Likelihood ratio (LR) tests gave an overall positive LR of 6.0 (95% CI, 3.6-9.7) and negative LR of 0.2 (95% CI, 0.14-0.31). The pooled diagnostic odds ratio was 29 (95% CI, 13-63). The summary receiver operating characteristic curve indicates that the area under the curve was 0.91 (95% CI, 0.88-0.93).

Conclusion: The current meta-analysis showed good sensitivity and specificity of F-18 FDG PET or PET/CT for detecting recurrent disease after curative resection of gastric cancer despite heterogeneity in ethnicity, recurrence rate, histology, and interpretation method.

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F-18 FDG PET或PET/CT对胃癌复发的诊断价值:一项系统综述和荟萃分析

背景:本系统综述和荟萃分析探讨了F-18氟脱氧葡萄糖(FDG)正电子发射断层扫描(PET)或PET/计算机断层扫描(PET/CT)对胃癌根治性切除术后疾病复发的诊断价值。方法:检索PubMed和Embase数据库，从最早可检索日期到2019年11月30日，检索评估F-18 FDG PET或PET/CT检测胃癌术后复发性疾病诊断性能的研究。结果:在17项研究(1732例患者)中，F-18 FDG PET或PET/CT的总敏感性为0.82(95%可信区间[CI]， 0.74-0.88)，异质性为I2=76.5(结论:本荟萃分析显示，尽管种族、复发率、组织学和解释方法存在异质性，但F-18 FDG PET或PET/CT检测胃癌根治性切除术后复发疾病的敏感性和特异性良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.