A Gadolinium-Based Magnetic Ionic Liquid for Dispersive Liquid-Liquid Microextraction of Ivermectin from Environmental Water.

IF 1.8 4区化学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of chromatographic science Pub Date : 2023-12-13 DOI:10.1093/chromsci/bmac101

Mohamed A Abdelaziz, Ahmed M Saleh, Fotouh R Mansour, Neil D Danielson

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引用次数: 0

Abstract

The recently introduced gadolinium-based magnetic ionic liquid (Gd-MIL) has been exploited as an extractant in dispersive liquid-liquid microextraction (DLLME) for preconcentration of ivermectin (IVR) from water samples followed by analysis using reversed-phase HPLC with UV detection at 245 nm. The utilized Gd-MIL extractant is hydrophobic with markedly high magnetic susceptibility. These features result in an efficient extraction of the lipophilic analyte and facilitate the phase separation under the influence of a strong magnetic field, thus promoting the method sensitivity and increasing the potential for automation. To maximize the IVR enrichment by DLLME, the procedure was optimized for extractant mass, dispersive solvent type/volume, salt addition and diluent pH. At optimized conditions, an enrichment factor approaching 70 was obtained with 4.0-mL sample sizes. The method was validated in terms of accuracy, precision, specificity and limit of quantitation. The method was successfully applied to the determination of IVR in river water samples with a mean relative recovery of 97.3% at a spiked concentration of 400 ng/mL. Compared with other reported methods, this approach used a simpler procedure with improved precision, lower amounts of safer solvents and a short analysis time.

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一种钆基磁性离子液体用于从环境水体中分散液-液微萃取伊维菌素

最近推出的钆基磁性离子液体（Gd-MIL）被用作分散液-液微萃取（DLLME）的萃取剂，用于预浓缩水样中的伊维菌素（IVR），然后使用反相高效液相色谱法进行分析，紫外检测波长为 245 nm。所使用的 Gd-MIL 萃取剂具有疏水性和明显的高磁感应强度。这些特点导致了亲脂性分析物的高效萃取，并促进了强磁场影响下的相分离，从而提高了方法的灵敏度并增加了自动化的潜力。为了最大限度地提高 DLLME 对 IVR 的富集效果，对萃取剂质量、分散溶剂类型/体积、盐添加量和稀释剂 pH 值进行了优化。在优化条件下，样品量为 4.0 毫升时，富集因子接近 70。该方法在准确度、精密度、特异性和定量限方面都得到了验证。该方法成功应用于河水样品中 IVR 的测定，在加标浓度为 400 ng/mL 时，平均相对回收率为 97.3%。与其他已报道的方法相比，该方法程序更简单，精密度更高，使用的溶剂量更少，分析时间更短。

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来源期刊

Journal of chromatographic science 化学-分析化学

CiteScore

2.90

自引率

7.70%

发文量

审稿时长

5.6 months

期刊介绍： The Journal of Chromatographic Science is devoted to the dissemination of information concerning all methods of chromatographic analysis. The standard manuscript is a description of recent original research that covers any or all phases of a specific separation problem, principle, or method. Manuscripts which have a high degree of novelty and fundamental significance to the field of separation science are particularly encouraged. It is expected the authors will clearly state in the Introduction how their method compares in some markedly new and improved way to previous published related methods. Analytical performance characteristics of new methods including sensitivity, tested limits of detection or quantification, accuracy, precision, and specificity should be provided. Manuscripts which describe a straightforward extension of a known analytical method or an application to a previously analyzed and/or uncomplicated sample matrix will not normally be reviewed favorably. Manuscripts in which mass spectrometry is the dominant analytical method and chromatography is of marked secondary importance may be declined.