Review of Literature on Akkermansia muciniphila and its Possible Role in the Etiopathogenesis and Therapy of Type 2 Diabetes Mellitus.

IF 0.6 Q4 ENDOCRINOLOGY & METABOLISM

Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2022-01-01 DOI:10.15605/jafes.037.01.13

Made Indira Dianti Sanjiwani, I Putu Hendri Aryadi, I Made Siswadi Semadi

引用次数: 3

Abstract

Akkermansia muciniphila is a promising gut microbiota for the treatment of type 2 diabetes mellitus (T2DM). A. muciniphila stimulates intestinal wall integrity, is an anti-inflammatory agent, and reduces endoplasmic reticulum stress, lipogenesis and gluconeogenesis. These properties make A. muciniphila a potential treatment option for T2DM by reducing insulin resistance and increasing insulin sensitivity and glucose tolerance in different tissues. This article explores the possible role of A. muciniphila in T2DM management, along with the various methods known to modulate A. muciniphila.

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嗜粘杆菌及其在2型糖尿病发病和治疗中的可能作用的文献综述。

嗜粘液阿克曼氏菌是治疗2型糖尿病(T2DM)的一种很有前途的肠道微生物群。嗜粘杆菌刺激肠壁完整性，是一种抗炎剂，并减少内质网应激，脂肪生成和糖异生。这些特性使嗜粘液芽胞杆菌成为T2DM的潜在治疗选择，可以降低胰岛素抵抗，增加不同组织的胰岛素敏感性和葡萄糖耐量。本文探讨嗜粘杆菌在T2DM治疗中的可能作用，以及调节嗜粘杆菌的各种已知方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the ASEAN Federation of Endocrine Societies ENDOCRINOLOGY & METABOLISM-

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The Journal of the ASEAN Federation of Endocrine Societies (JAFES) is an OPEN ACCESS, internationally peer-reviewed, English language, medical and health science journal that is published in print two times a year by the ASEAN Federation of Endocrine Societies. It shall serve as the endocrine window between the ASEAN region and the world, featuring original papers and publishing key findings from specialists and experts of endocrinology.