Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2023-12-01 DOI:10.1016/j.cytogfr.2023.08.002

Xinyu Tian , Ting Wang , Han Shen , Shengjun Wang

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Abstract

Myeloid-derived suppressor cells (MDSCs) are important components of the tumor microenvironment (TME), which drive the tumor immune escape by inducing immunosuppression. The expansion and function of MDSCs are tightly associated with signaling pathways induced by molecules from tumor cells, stromal cells, and activated immune cells in the TME. Although these pathways have been well-characterized, the understanding of the epigenetic regulators involved is incomplete. Since histone modifications are the most studied epigenetic changes in MDSCs, we summarize current knowledge on the role of histone modifications in MDSCs within this review. We first discuss the influence of the TME on histone modifications in MDSCs, with an emphasis on histone modifications and modifiers that direct MDSC differentiation and function. Furthermore, we highlight current epigenetic interventions that can reverse MDSC-induced immunosuppression by modulating histone modifications and discuss future research directions to fully appreciate the role of histone modifications in MDSCs.

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肿瘤微环境、组蛋白修饰和髓源性抑制细胞

髓源性抑制细胞(myelelod -derived suppressor cells, MDSCs)是肿瘤微环境(tumor microenvironment, TME)的重要组成部分，通过诱导免疫抑制来驱动肿瘤免疫逃逸。MDSCs的扩增和功能与TME中肿瘤细胞、基质细胞和活化免疫细胞分子诱导的信号通路密切相关。虽然这些途径已被很好地表征，但对所涉及的表观遗传调控因子的理解是不完整的。由于组蛋白修饰是MDSCs中研究最多的表观遗传变化，我们在本综述中总结了组蛋白修饰在MDSCs中作用的现有知识。我们首先讨论了TME对MDSC中组蛋白修饰的影响，重点是组蛋白修饰和修饰剂，这些修饰剂指导MDSC的分化和功能。此外，我们强调了当前的表观遗传干预可以通过调节组蛋白修饰逆转MDSCs诱导的免疫抑制，并讨论了未来的研究方向，以充分认识组蛋白修饰在MDSCs中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.