Does the Presence of Extended Jugular Lymphatic Sacs Add More Risk to Nuchal Thickness for Genetic and Structural Abnormality?

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Medical Ultrasound Pub Date : 2023-04-01 DOI:10.4103/jmu.jmu_225_21

Mehmet Obut, Arife Akay, Ibanoglu Can Müjde, Özge Yucel Çelik, Asya Kalayci Öncü, Zuat Acar, Erdal Seker, Erkan Saglam, Cantekin Iskender

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Abstract

Background: The risks added by extended jugular lymphatic sacs (EJLS) to increased nuchal translucency (NT) including genetic and structural abnormalities and pregnancy outcomes have not been previously investigated, which this study aims to investigate.

Methods: The data of 155 singleton pregnancies with increased fetal NT (≥95^th percentile) of these 20 with fetal EJLS were evaluated retrospectively. Patients were stratified according to NT thickness such that ≥95^th percentile - 3.5 mm, 3.6-4.4 mm, 4.5-5.4 mm, 5.5-6.4 mm, ≥6.5 mm, and grouped according to the presence of EJLS. Pregnancy outcomes, genetic and structural abnormalities were assessed by comparing EJLS with non-EJSL cases (n-EJLS).

Results: Associated with NT, the incidence of the presence of EJLS increased with NT, from 4.5% at the ≥95^th percentile - 3.5 mm to 30.8% when NT ≥5.5 mm. In the n-EJLS group, the proportion of fetuses with structural and genetic abnormalities increased as the measurement of NT increased. This correlation was not observed in the EJLS group. Compared to n-EJLS, cases with EJLS had a higher rate of fetal structural (38.5% vs. 75%, P = 0.003) and genetic (18.5% vs. 45%, P = 0.005) anomalies and a lower term live birth rate (59.3% vs. 15%, P < 0.001).

Conclusion: The increasing rate of EJLS was seen as NT increased. Compared to n-EJLS, the EJLS cases had a higher rate poor pregnancy outcomes and fetal genetic and structural abnormalities.

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颈静脉淋巴囊延伸是否增加颈颈部遗传和结构异常的风险?

背景:颈静脉淋巴囊(EJLS)延长对颈透明(NT)增加的风险，包括遗传和结构异常以及妊娠结局，以前没有研究过，本研究旨在探讨。方法:回顾性分析20例EJLS胎儿NT增高(≥95百分位数)的155例单胎妊娠的资料。根据NT厚度≥95个百分点- 3.5 mm、3.6-4.4 mm、4.5-5.4 mm、5.5-6.4 mm、≥6.5 mm进行分层，并根据是否存在EJLS进行分组。通过比较EJLS和非EJLS (n-EJLS)来评估妊娠结局、遗传和结构异常。结果:与NT相关，EJLS的发生率随NT的增加而增加，从≥95百分位- 3.5 mm时的4.5%增加到NT≥5.5 mm时的30.8%。在n-EJLS组中，随着NT测量的增加，结构和遗传异常的胎儿比例增加。在EJLS组中没有观察到这种相关性。与n-EJLS相比，EJLS的胎儿结构异常率(38.5%比75%，P = 0.003)和遗传异常率(18.5%比45%，P = 0.005)较高，足月活产率(59.3%比15%，P < 0.001)较低。结论:EJLS随NT的增加而增加。与n-EJLS相比，EJLS患者妊娠结局不良和胎儿遗传和结构异常的发生率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Ultrasound RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

9.10%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Medical Ultrasound is the peer-reviewed publication of the Asian Federation of Societies for Ultrasound in Medicine and Biology, and the Chinese Taipei Society of Ultrasound in Medicine. Its aim is to promote clinical and scientific research in ultrasonography, and to serve as a channel of communication among sonologists, sonographers, and medical ultrasound physicians in the Asia-Pacific region and wider international community. The Journal invites original contributions relating to the clinical and laboratory investigations and applications of ultrasonography.