Effects of LED photobiomodulation therapy on the subcutaneous fatty tissue of obese individuals - histological and immunohistochemical analysis.

IF 1.2 4区医学 Q3 DERMATOLOGY

Journal of Cosmetic and Laser Therapy Pub Date : 2022-11-17 DOI:10.1080/14764172.2022.2109677

Débora Aparecida Oliveira Modena, Ciro Dantas Soares, Cintia Cristina Santi Martignago, Stephani Almeida, Everton Cazzo, Elinton Adami Chaim

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引用次数: 1

Abstract

Photobiomodulation therapy (PBMT) has become an adjuvant therapeutic possibility in body remodeling procedures. Given this scenario, this study was proposed with the aim of evaluating the effects of PBMT to Light Emitting Diode (LED) associating the red (630 nm) and infrared (850 nm) wavelengths in the subcutaneous fatty tissue. This controlled study of comparative intervention that evaluated a sample of subcutaneous fatty tissue from women with grade II obesity. The participants received the LED PBMT treatment with associated red and infrared wavelengths sequentially on the left side of the abdomen and the right side was considered as control, with the collection of biological material performed at the time of bariatric surgery. For histological and immunohistochemical evaluation, Caspase 3, Cleaved Caspase 3, CD68+, HSL and adipophilin markers were used. The participants showed positivity in the expression of Caspase 3 and Cleaved Caspase (p < .0001), CD68+ macrophages (p < .0001), HSL (p < .0001) and adipophilin (p < .0013) in the intervention sample when compared to the control. PBMT and LED associating red and infrared wavelengths were able to promote autophagic lipolysis induced by adipocyte cell apoptosis in the subcutaneous tissue of obese individuals.

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LED光生物调节疗法对肥胖个体皮下脂肪组织的影响——组织学和免疫组织化学分析。

光生物调节治疗(PBMT)已成为一种辅助治疗的可能性在身体重塑过程。在这种情况下，本研究的目的是评估PBMT对皮下脂肪组织中红光(630 nm)和红外线(850 nm)波长的发光二极管(LED)的影响。这是一项比较干预的对照研究，评估了II级肥胖妇女的皮下脂肪组织样本。参与者在腹部左侧和右侧依次接受相关红光和红外线波长的LED PBMT治疗，并在减肥手术时进行生物材料收集。采用Caspase 3、Cleaved Caspase 3、CD68+、HSL和亲脂素标记进行组织学和免疫组化评价。参与者的Caspase 3和Cleaved Caspase表达呈阳性(p

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来源期刊

Journal of Cosmetic and Laser Therapy DERMATOLOGY-SURGERY

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： A unique journal that focuses on the application of cosmetic laser and light therapies on the skin. The Journal of Cosmetic & Laser Therapy provides a forum for stimulating and up-to-date studies demonstrating the wide range of therapeutic options for clinicians and surgeons involved in cosmetic and dermatological treatment. The journal is aimed at dermatologists, cosmetic surgeons, plastic and facial plastic surgeons, oculoplastic surgeons and all those interested in the rapidly expanding field of cosmetic and laser therapy. Features include: -Cosmetic surgery, including facial rejuvenation, hair removal and skin resurfacing -Use of lasers and other light sources for cosmetic and dermatological treatment -Applications of peeling agents, fillers, injectables, implants and other cosmetic modalities -Topical treatments -Practical tips and safety issues