Implication of KDM6A in bladder cancer.

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Pharmacogenomics Pub Date : 2023-06-01 DOI:10.2217/pgs-2023-0027

Marianne Matar, Gilles Prince, Ibrahim Hamati, Maria Baalbaky, Jonas Fares, Marc Aoude, Charbel Matar, Hampig Raphael Kourie

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引用次数: 0

Abstract

Background: Bladder cancer is a common urogenital malignancy characterized by frequent genetic alterations. Histone demethylase gene KDM6A is commonly mutated in bladder cancer. Aim: To review the characteristics of KDM6A and its mutation consequences, and to introduce a potential KDM6A-targeted treatment. Methods: We conducted a comprehensive literature search using two electronic databases, MEDLINE and Cochrane Library, to retrieve topic-related articles from July 2013 to July 2022 using keywords 'KDM6A', 'bladder cancer', 'UTX', 'treatment' and 'mutation'. Five reviewers independently screened literature search results and abstracted data from included studies. Descriptive analysis was conducted and 30 articles were retained. Main Results: A total of 30 articles were retrieved. Experimental and clinical data were collected and grouped by theme. Therapeutic strategies are depicted and organized by tables for a better understanding. Conclusion: This review demonstrates that KDM6A has crucial implications in bladder cancer pathogenesis and treatment.

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KDM6A在膀胱癌中的意义。

背景:膀胱癌是一种常见的泌尿生殖系统恶性肿瘤，其特征是基因改变频繁。组蛋白去甲基化酶基因KDM6A通常在膀胱癌中发生突变。目的:综述KDM6A的特征及其突变后果，并介绍一种潜在的针对KDM6A的治疗方法。方法:我们使用MEDLINE和Cochrane Library两个电子数据库进行全面的文献检索，检索2013年7月至2022年7月期间与主题相关的文章，检索关键词为“KDM6A”、“膀胱癌”、“UTX”、“治疗”和“突变”。五名审稿人独立筛选文献检索结果并从纳入的研究中提取数据。进行描述性分析，保留30篇文章。主要结果:共检索到30篇文献。收集实验及临床资料，按主题分组。为了更好地理解，治疗策略被描绘和组织成表格。结论:KDM6A在膀胱癌的发病机制和治疗中具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.