{"title":"Advances in microbial production of feed amino acid.","authors":"Kuo Zhao, Jianmin Liu, Cong Gao, Jia Liu, Xiulai Chen, Liming Liu, Liang Guo","doi":"10.1016/bs.aambs.2022.05.001","DOIUrl":null,"url":null,"abstract":"<p><p>Feed amino acids have numerous applications, and the market demand for them is likely to grow. Microbial cell factories promise the sustainable production of feed amino acids; however, their performance is significantly affected by the availability of precursors, carbon metabolic flux, and transporter systems. To circumvent these potential roadblocks, high-performance microbial cell factories have been constructed by strengthening the supply of precursors, increasing metabolic pathway flux, and engineering transporters. In this review, limiting factors and recent technical advances affecting the production of feed amino acids in microbial cell factories are discussed. In addition, existing challenges and potential strategies for increasing the output of these amino acids are described.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":"119 ","pages":"1-33"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in applied microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.aambs.2022.05.001","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Immunology and Microbiology","Score":null,"Total":0}
引用次数: 1
Abstract
Feed amino acids have numerous applications, and the market demand for them is likely to grow. Microbial cell factories promise the sustainable production of feed amino acids; however, their performance is significantly affected by the availability of precursors, carbon metabolic flux, and transporter systems. To circumvent these potential roadblocks, high-performance microbial cell factories have been constructed by strengthening the supply of precursors, increasing metabolic pathway flux, and engineering transporters. In this review, limiting factors and recent technical advances affecting the production of feed amino acids in microbial cell factories are discussed. In addition, existing challenges and potential strategies for increasing the output of these amino acids are described.
期刊介绍：
Advances in Applied Microbiology offers intensive reviews of the latest techniques and discoveries in this rapidly moving field. The editors are recognized experts and the format is comprehensive and instructive.
Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology.
Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays.
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