Pregnancy and delivery in patients with Charcot-Marie-Tooth disease and related disorders.

IF 0.8 Q4 OBSTETRICS & GYNECOLOGY

Obstetric Medicine Pub Date : 2023-06-01 DOI:10.1177/1753495X221107328

Mariola Skorupinska, Gita Ramdharry, Bridgette Byrne, Matilde Laurá, Mary M Reilly

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引用次数: 1

Abstract

Background: Charcot-Marie-Tooth disease is the most common inherited peripheral neuropathy and many patients with Charcot-Marie-Tooth are women of childbearing age. Guidelines for managing pregnancy in Charcot-Marie-Tooth are lacking.

Aims: To assess the impact of pregnancy on Charcot-Marie-Tooth and how Charcot-Marie-Tooth affects pregnancy, delivery and postnatal care.

Methods: A retrospective questionnaire exploring disease course during pregnancy, delivery, pregnancy complications, anaesthetic management and puerperium was administered to 92 patients with Charcot-Marie-Tooth and related disorders.

Results: Worsening of Charcot-Marie-Tooth symptoms were reported in 37% of pregnant patients which resolved after delivery in half of the patients. No significant increase in pregnancy, delivery and anaesthetic complications were observed and the type of delivery did not significantly differ from the normal population.

Conclusions: While these results are reassuring, ideally an international prospective study should be done to confirm these results and to develop practice guidelines on the management of pregnancy in Charcot-Marie-Tooth.

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沙克-玛丽-图斯病及相关疾病患者的妊娠和分娩

背景:腓骨肌萎缩症是最常见的遗传性周围神经病变，许多腓骨肌萎缩症患者为育龄妇女。夏可-玛丽-图斯缺乏妊娠管理指南。目的:评估妊娠对Charcot-Marie-Tooth的影响，以及Charcot-Marie-Tooth如何影响妊娠、分娩和产后护理。方法:对92例患有腓骨肌痛及相关疾病的患者进行回顾性问卷调查，探讨其妊娠、分娩、妊娠并发症、麻醉管理及产褥期的病程。结果:37%的妊娠患者出现腓骨肌痛症状加重，半数患者分娩后症状消失。妊娠、分娩和麻醉并发症未见明显增加，分娩方式与正常人群无明显差异。结论:虽然这些结果令人放心，但理想情况下，应该进行一项国际前瞻性研究来证实这些结果，并制定关于夏-玛丽-图斯妊娠管理的实践指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obstetric Medicine OBSTETRICS & GYNECOLOGY-

CiteScore

1.90

自引率

0.00%

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