MMN and P3a Elicited by a Novelty Oddball Paradigm Are Not Reduced in Early-Phase Psychosis.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2022-01-01 DOI:10.1159/000526745

Hayley Riel, Erica Rudolph, Catrina MacPhee, Philip G Tibbo, Derek J Fisher

引用次数: 0

Abstract

Introduction: The present study compared the mismatch negativity (MMN) and P3a waveforms among early-phase psychosis (EPP; n = 13) individuals and healthy controls (n = 30) to contribute to the research on these waveforms as potential biomarkers for schizophrenia.

Methods: MMN and P3a were elicited with a novelty paradigm using complex stimuli with electrophysiological technology.

Results: No significant group differences of amplitude were observed with either waveform. Increased asociality and blunted affect were associated with a reduction in both MMN and P3a waveforms indicating a relationship between these negative symptoms and cognitive deficits. Good social and occupational functioning correlated with improved MMN and P3a waveforms in the EPP group.

Conclusions: This study suggests that MMN and P3a may be more appropriately used as an indicator of illness progression and symptomology rather than a biomarker in the early phase of the illness.

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由新奇古怪范式诱发的MMN和P3a在早期精神病患者中并未减少。

前言:本研究比较了早期精神病患者(EPP;N = 13)名个体和健康对照(N = 30)对这些波形作为精神分裂症潜在生物标志物的研究做出贡献。方法:采用电生理复杂刺激技术，采用新颖范式诱导MMN和P3a。结果:两种波形振幅组间无明显差异。社会性的增加和迟钝的影响与MMN和P3a波形的减少有关，这表明这些阴性症状与认知缺陷之间存在关系。EPP组良好的社会和职业功能与MMN和P3a波形改善相关。结论:本研究表明MMN和P3a可能更适合作为疾病进展和症状的指标，而不是疾病早期的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.