Ginsenoside Rg1 modulates intestinal microbiota and supports re-generation of immune cells in dexamethasone-treated mice.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Sabiha Yousuf, He Liu, Zhang Yingshu, Danish Zahid, Hassan Ghayas, Ming Li, Yan Ding, Wenzhe Li
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引用次数: 3

Abstract

Ginsenoside Rg1 is one of the major ginsenosides found in roots of Panax ginseng and Panax notoginseng. Ginsenoside Rg1 is known to possess various biological activities including immunity enhancement activity. However, it is not clear whether the regulation of immune function by Rg1 is related to the intestinal microbiota. In the present study, the immuno-modulatory and gut microbiota-reshaping effects of ginsenoside Rg1 were evaluated. Ginsenoside Rg1 acts as an immune-enhancing agent to increase spleen index and the number of T, B and dendritic cells in dexamethasone (Dex)-treated mice. Ginsenoside Rg1 also increased the production of sIgA and regulated the expression of interleukin 2 (IL-2), IL-4, IL-10 and IFN-γ. Meanwhile, Rg1 administration regulated the structure of intestinal microbiota. The relative abundance of mouse intestinal microbial groups, such as Alistipes, Ruminococcaceae, Lachnospiraceae, and Roseburia were increased by Rg1 administration, whereas a decrease in the potential pathogens like Helicobacteraceae, Dubosiella, Mycoplasma, Alloprevotella, Allobaculum was observed. Moreover, Rg1 metabolites of Lachnospiraceae bacterium enhanced the proliferation of CD4+ T cells and T regulatory (Treg) cells. Ginsenoside Rg1 improved the inflammatory condition of the colonic tissue and repaired the destructed mucosal barrier. This study suggested that Rg1 strengthens immunity with regulating the homeostasis of intestinal microbiota in mice.

人参皂苷Rg1调节地塞米松处理小鼠肠道微生物群并支持免疫细胞再生。
人参皂苷Rg1是人参和三七根中发现的主要人参皂苷之一。人参皂苷Rg1具有多种生物活性,包括免疫增强活性。然而,Rg1对免疫功能的调节是否与肠道菌群有关尚不清楚。本研究评估了人参皂苷Rg1的免疫调节和肠道菌群重塑作用。人参皂苷Rg1作为免疫增强剂,可增加地塞米松(Dex)处理小鼠脾指数和T、B、树突状细胞数量。人参皂苷Rg1还能增加sIgA的产生,调节白细胞介素2 (IL-2)、IL-4、IL-10和IFN-γ的表达。同时,Rg1可调节肠道菌群结构。Rg1组小鼠肠道微生物群Alistipes、Ruminococcaceae、Lachnospiraceae和Roseburia的相对丰度增加,而潜在致病菌Helicobacteraceae、Dubosiella、Mycoplasma、Alloprevotella、Allobaculum的相对丰度降低。此外,毛螺科细菌Rg1代谢物可促进CD4+ T细胞和T调节(Treg)细胞的增殖。人参皂苷Rg1改善了结肠组织的炎症状况,修复了被破坏的粘膜屏障。本研究提示Rg1通过调节小鼠肠道菌群的稳态来增强免疫。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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