Recovery of spermatogenesis after androgenic anabolic steroids abuse in men. A systematic review of the literature

Actas urologicas espanolas Pub Date : 2024-03-01 DOI:10.1016/j.acuroe.2023.07.007

O. Rajmil , J. Moreno- Sepulveda

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Abstract

Objective

This systematic review aims to evaluate the optimal treatment for male infertility resulting from Anabolic Androgenic Steroids (AAS) abuse.

Methods

A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies that compared different protocols for the recovery of spermatogenesis in patients after AAS use were included.

Results

13 studies investigating different protocols to restore spermatogenesis in patients with AAS abuse met the inclusion criteria. The available agents that showed restoration of spermatogenesis include injectable gonadotropins, selective estrogen receptor modulators, and aromatase inhibitors, but their use is still poorly described in the literature.

Conclusions

Clinicians need to be aware of the detrimental effects of AAS on spermatogenesis. AAS-associated infertility may be reversible, but sperm production may take over a year to normalize. Both conservative and aggressive treatment can boost spermatogenesis with positive results. Further understanding of male reproductive endocrinology and high-quality data on the field of restoration of spermatogenesis after AAS abuse are warranted.

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男性滥用雄性合成类固醇后精子生成的恢复。文献系统回顾。

目的本系统综述旨在评估合成代谢雄性类固醇（AAS）滥用导致的男性不育症的最佳治疗方法：方法：根据系统综述和元分析首选报告项目（PRISMA）声明进行系统综述。结果：13 项研究调查了不同的精子发生恢复方案：13项研究调查了不同的方案，以恢复滥用AAS患者的生精功能，符合纳入标准。可用于恢复精子生成的药物包括注射用促性腺激素、选择性雌激素受体调节剂和芳香化酶抑制剂，但文献中对这些药物的使用情况仍描述不清：结论：临床医生需要意识到AAS对精子发生的有害影响。AAS相关不育症可能是可逆的，但精子生成可能需要一年多的时间才能恢复正常。保守治疗和积极治疗都能促进精子生成，并取得积极效果。我们有必要进一步了解男性生殖内分泌学，并提供滥用 AAS 后精子生成恢复方面的高质量数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Actas urologicas espanolas

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