Coagulation parameters and Apgar score are associated with severity in preterm infants.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2022-08-01 DOI:10.26355/eurrev_202208_29417

F-Y Zhou, H-R Xiong, Y-P Luo, S-H Zhen, L Yuan, H Min

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引用次数: 1

Abstract

Objective: Coagulation parameters are used to diagnose hematological diseases. The correlation between the coagulation parameters and Apgar score at 5 min is yet to be elucidated. The present study aimed at describing the neonatal coagulation parameters in preterm infants with a low Apgar score at 5 min.

Patients and methods: In this case-control study, 32 serious preterm infants were compared with 20 preterm infants, according to the Apgar score at 5 min. The prothrombin time (PT), thrombin time (TT), fibrinogen (Fbg), activated partial thromboplastin time (APTT), calculated international normalized ratio (INR), D-dimer (D2), fructose diphosphate sodium (FDP), and procalcitonin (PCT) values were recorded. The linear correlation between coagulation parameters and Apgar score at 5 min was analyzed by linear regression. The two groups were compared using GraphPad Prism 8 (LaJolla, CA, USA).

Results: In the study, the mean coagulation parameters were significantly higher in the serious preterm infants with low the Apgar score at 5 min compared to the preterm infants with normal Agar scores at 5 min (p<0.05). The correlation between coagulation parameters and Apgar score at 5 min was recorded (PT: R=0.3984; APTT: R=0.3165; INR: R=0.4139).

Conclusions: The coagulation parameters were significantly higher in serious preterm infants with a low Apgar score at 5 min. Also, the coagulation parameters and Apgar score at 5 min are associated with severity in preterm infants.

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凝血参数和Apgar评分与早产儿严重程度相关。

目的:应用凝血指标诊断血液病。凝血参数与5min时Apgar评分的相关性尚不清楚。本研究旨在描述低Apgar评分早产儿在5分钟时的新生儿凝血参数。在本病例对照研究中，根据5分钟Apgar评分，将32例重度早产儿与20例早产儿进行比较。记录凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(Fbg)、活化部分凝血活素时间(APTT)、计算国际标准化比率(INR)、d -二聚体(D2)、果糖二磷酸钠(FDP)和降钙素原(PCT)值。采用线性回归分析5 min时凝血参数与Apgar评分的线性相关性。两组比较采用GraphPad Prism 8 (LaJolla, CA, USA)。结果:在本研究中，低Apgar评分的严重早产儿的平均凝血参数在5分钟时明显高于正常Agar评分的早产儿(p结论:低Apgar评分的严重早产儿的凝血参数在5分钟时明显高于正常Apgar评分的早产儿。并且，5分钟时的凝血参数和Apgar评分与早产儿的严重程度相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)