Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis.

IF 3.6 3区医学 Q1 PSYCHIATRY

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-09-17 DOI:10.47626/1516-4446-2023-3095

Gustavo Magno Baldin Tiguman, Rogério Hoefler, Marcus Tolentino Silva, Vanessa Gomes Lima, Inês Ribeiro-Vaz, Taís Freire Galvão

{"title":"Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis.","authors":"Gustavo Magno Baldin Tiguman, Rogério Hoefler, Marcus Tolentino Silva, Vanessa Gomes Lima, Inês Ribeiro-Vaz, Taís Freire Galvão","doi":"10.47626/1516-4446-2023-3095","DOIUrl":null,"url":null,"abstract":"Objectives: To estimate the prevalence of antidepressant use in Brazil.Methods: We conducted a systematic review with searches in MEDLINE, Embase, Scopus, LILACS, and SciELO up to May 2023. Two researchers independently selected studies, extracted data, and assessed the methodological quality. We pooled the prevalence of antidepressant use using meta-analyses of proportions (Freeman-Tukey transformation) and estimated heterogeneity by the I2 statistic. OR meta-analyses of antidepressant use by sex were calculated (men as reference) and between-study variation was explored by meta-regressions.Results: Out of 3,299 records retrieved, 23 studies published in 28 reports were included, with a total of 75,061 participants. The overall prevalence of antidepressant use was 4.0% (95%CI 2.7-5.6%; /² = 98.5%). Use of antidepressants in the previous 3 days was higher in women (12.0%; 95%CI 9.5-15.1%; /² = 0%) than men (4.6%; 95%CI 3.1-6.8%; /² = 0%) (p < 0.001; OR = 2.82; 95%CI 1.72-4.62). Gender differences were particularly higher for antidepressant use in the previous year (women: 2.3%; 95%CI 1.6-3.1; /² = 37.6% vs. men: 0.5%; 95%CI 0.2-1.0%; /² = 0%, p < 0.001; OR = 4.18; 95%CI 2.10-8.30). Between-study variation in the overall prevalence of antidepressant use significantly increased with mean participant age (p = 0.035; residual /² = 0%; regression coefficient = 0.003).Conclusion: Four out of every 100 Brazilians used antidepressants in this 3-decade assessment. Use increased with age and was more prevalent in women compared to men.Registration number: PROSPERO CRD42022345332.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233095"},"PeriodicalIF":3.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189131/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Brasileira de Psiquiatria","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47626/1516-4446-2023-3095","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/17 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: To estimate the prevalence of antidepressant use in Brazil.

Methods: We conducted a systematic review with searches in MEDLINE, Embase, Scopus, LILACS, and SciELO up to May 2023. Two researchers independently selected studies, extracted data, and assessed the methodological quality. We pooled the prevalence of antidepressant use using meta-analyses of proportions (Freeman-Tukey transformation) and estimated heterogeneity by the I2 statistic. OR meta-analyses of antidepressant use by sex were calculated (men as reference) and between-study variation was explored by meta-regressions.

Results: Out of 3,299 records retrieved, 23 studies published in 28 reports were included, with a total of 75,061 participants. The overall prevalence of antidepressant use was 4.0% (95%CI 2.7-5.6%; /² = 98.5%). Use of antidepressants in the previous 3 days was higher in women (12.0%; 95%CI 9.5-15.1%; /² = 0%) than men (4.6%; 95%CI 3.1-6.8%; /² = 0%) (p < 0.001; OR = 2.82; 95%CI 1.72-4.62). Gender differences were particularly higher for antidepressant use in the previous year (women: 2.3%; 95%CI 1.6-3.1; /² = 37.6% vs. men: 0.5%; 95%CI 0.2-1.0%; /² = 0%, p < 0.001; OR = 4.18; 95%CI 2.10-8.30). Between-study variation in the overall prevalence of antidepressant use significantly increased with mean participant age (p = 0.035; residual /² = 0%; regression coefficient = 0.003).

Conclusion: Four out of every 100 Brazilians used antidepressants in this 3-decade assessment. Use increased with age and was more prevalent in women compared to men.

Registration number: PROSPERO CRD42022345332.

查看原文本刊更多论文

巴西使用抗抑郁药的普遍程度：系统回顾与荟萃分析。

目的：估算巴西抗抑郁药物的使用率：估算巴西抗抑郁药物的使用率：我们对截至 2023 年 5 月的 MEDLINE、Embase、Scopus、LILACS 和 SciELO 进行了系统性检索。两名研究人员独立选择研究、提取数据并评估方法学质量。我们利用比例荟萃分析（Freeman-Tukey 转换）对抗抑郁药的使用率进行了汇总，并利用 I2 统计量估算了异质性。按性别计算抗抑郁药使用的OR元分析（以男性为参照），并通过元回归探讨研究间的差异：在检索到的 3,299 条记录中，纳入了 28 份报告中发表的 23 项研究，共有 75,061 名参与者。使用抗抑郁药的总体流行率为 4.0% (95%CI 2.7-5.6%; /² = 98.5%)。女性（12.0%；95%CI 9.5-15.1%；/² = 0%）比男性（4.6%；95%CI 3.1-6.8%；/² = 0%）在过去 3 天内使用抗抑郁药的比例更高（P < 0.001；OR = 2.82；95%CI 1.72-4.62）。上一年使用抗抑郁药的性别差异尤其大（女性：2.3%；95%CI 1.6-3.1；/² = 37.6%；男性：0.5%；95%CI 0.2-1.0%；/² = 0%，p < 0.001；OR = 4.18；95%CI 2.10-8.30）。使用抗抑郁药的总体流行率在研究间的差异随参与者平均年龄的增加而显著增加（p = 0.035；残差/² = 0%；回归系数 = 0.003）：结论：在这次为期 3 年的评估中，每 100 名巴西人中就有 4 人使用抗抑郁药。使用率随年龄增长而增加，女性比男性更普遍：ProCORMBERCO CRD42022345332.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revista Brasileira de Psiquiatria 医学-精神病学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.